J 2023

SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

DE LUCA, Giuseppe, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV et. al.

Basic information

Original name

SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Authors

DE LUCA, Giuseppe, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Zan ZIMBAKOV, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura I FERRER, Alexandre QUADROS, Marek MILEWSKI, Di Uccio Fortunato SCOTTO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA (203 Czech Republic, belonging to the institution), Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor M BECERRA-MUNOZ, Michael Kang-Yin LEE, Dafsah Arifa JUZAR, Rodrigo de Moura JOAQUIM, De Simone CIRO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Lux ARPAD, Lucia MARINUCCI, Vincenzo GUIDUCCI, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Vincent FLAVIEN, Enrico FABRIS, Inigo Lozano MARTINEZ-LUENGAS, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO-SILBERMANN, Santiago ORDONEZ, Alev Arat OZKAN, Bruno SCHELLER, Heidi LEHTOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Joao Antonio Brum SILVEIRA, Ivan BESSONOV, Rodrigo ZONI, Stefano SAVONITTO, George KOCHIADAKIS, Dimitrios ALEXOPOULOS, Carlos E URIBE, John KANAKAKIS, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie Chor-Cheung TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Anne BELLEMAIN-APPAIX, Gustavo PESSAH, Giuliana CORTESE, Guido PARODI, Mohammed Abed BURGADHA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA, Matteo NARDIN and Monica VERDOIA

Edition

ANGIOLOGY, THOUSAND OAKS, SAGE PUBLICATIONS INC, 2023, 0003-3197

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.800 in 2022

RIV identification code

RIV/00216224:14110/23:00130263

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1177/00033197221129351

UT WoS

000866193900001

Keywords in English

thrombosis; STEMI; outcome

Tags

14110211, rivok

Tags

International impact, Reviewed
Změněno: 26/1/2024 10:59, Mgr. Tereza Miškechová

Abstract

V originále

SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P = .002), less often active smokers (P = .002), and hypercholesterolemic (P = .006), they presented more often later than 12 h (P = .037), more often to the hub and were more often in cardiogenic shock (P = .02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P < .0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P = .029) and more thrombectomy (P = .046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P < .001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P < .001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P < .001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.
Displayed: 1/11/2024 08:39