Detailed Information on Publication Record
2022
Vagus nerve stimulation outcome prediction: from simple parameters to advanced models
CHRASTINA, Jan, Zdeněk NOVÁK, Tomáš ZEMAN, Irena DOLEŽALOVÁ, Eva ZATLOUKALOVÁ et. al.Basic information
Original name
Vagus nerve stimulation outcome prediction: from simple parameters to advanced models
Authors
CHRASTINA, Jan (203 Czech Republic, guarantor, belonging to the institution), Zdeněk NOVÁK (203 Czech Republic, belonging to the institution), Tomáš ZEMAN (203 Czech Republic, belonging to the institution), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Eva ZATLOUKALOVÁ (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)
Edition
Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2022, 0006-9248
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30210 Clinical neurology
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.500
RIV identification code
RIV/00216224:14110/22:00129736
Organization unit
Faculty of Medicine
UT WoS
000903730000006
Keywords in English
KEY WORDS; epilepsy; vagus nerve stimulation; response predictor; EEG
Tags
International impact, Reviewed
Změněno: 2/2/2023 13:54, Mgr. Tereza Miškechová
Abstract
V originále
Since its approval as an adjunct treatment for refractory partial epilepsy, the positive effects of vagus nerve stimulation (VNS) on seizure frequency and severity have been supported by many studies. Seizure reduction of more than 50 % can be expected in at least 50 % of patients. However, a complete post-VNS seizure freedom is rarely achieved and 25 % of patients do not benefit from VNS. Our study provides an overview of the potential predictors of VNS response, from the most simple and basic data to sophisticated EEG processing studies and functional imaging studying brain connectivity. The data support better outcomes in younger patients with early VNS implantation, in patients with posttraumatic epilepsy or tuberous sclerosis, and in patients without bilateral interictal epileptiform discharges. The variability of heart activity has also been studied with some promising results. Because the generally accepted hypothesis of the VNS mechanism is the modulation of synaptic activity in multiple cortical and subcortical regions of the brain, the studies of brain response to external stimulation and/or of brain connectivity were used for models predicting the effect of VNS in individual patients. Although the predictive value of these models is high, the required special equipment and sophisticated mathematical tools limit their routine use (Ref. 58).
Links
| NV19-04-00343, research and development project |
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