FRIEDLOVÁ, Nela, Filip Zavadil KOKÁŠ, Ted R HUPP, Bořivoj VOJTĚŠEK and Marta NEKULOVÁ. IFITM protein regulation and functions: Far beyond the fight against viruses. Frontiers in immunology. Frontiers Media S.A., 2022, vol. 13, November, p. 1-24. ISSN 1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2022.1042368.
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Basic information
Original name IFITM protein regulation and functions: Far beyond the fight against viruses
Authors FRIEDLOVÁ, Nela (203 Czech Republic, belonging to the institution), Filip Zavadil KOKÁŠ, Ted R HUPP, Bořivoj VOJTĚŠEK and Marta NEKULOVÁ (guarantor).
Edition Frontiers in immunology, Frontiers Media S.A. 2022, 1664-3224.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 7.300
RIV identification code RIV/00216224:14310/22:00128462
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3389/fimmu.2022.1042368
UT WoS 000893123200001
Keywords in English interferon-induced transmembrane proteins; tumor progression; therapy resistance; stem cells; immunity; tumor immunosurveillance
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 31/1/2023 16:26.
Abstract
Interferons (IFNs) are important cytokines that regulate immune responses through the activation of hundreds of genes, including interferon-induced transmembrane proteins (IFITMs). This evolutionarily conserved protein family includes five functionally active homologs in humans. Despite the high sequence homology, IFITMs vary in expression, subcellular localization and function. The initially described adhesive and antiproliferative or pro-oncogenic functions of IFITM proteins were diluted by the discovery of their antiviral properties. The large set of viruses that is inhibited by these proteins is constantly expanding, as are the possible mechanisms of action. In addition to their beneficial antiviral effects, IFITM proteins are often upregulated in a broad spectrum of cancers. IFITM proteins have been linked to most hallmarks of cancer, including tumor cell proliferation, therapeutic resistance, angiogenesis, invasion, and metastasis. Recent studies have described the involvement of IFITM proteins in antitumor immunity. This review summarizes various levels of IFITM protein regulation and the physiological and pathological functions of these proteins, with an emphasis on tumorigenesis and antitumor immunity.
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