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@article{2251565, author = {Friedlová, Nela and Kokáš, Filip Zavadil and Hupp, Ted R and Vojtěšek, Bořivoj and Nekulová, Marta}, article_number = {November}, doi = {http://dx.doi.org/10.3389/fimmu.2022.1042368}, keywords = {interferon-induced transmembrane proteins; tumor progression; therapy resistance; stem cells; immunity; tumor immunosurveillance}, language = {eng}, issn = {1664-3224}, journal = {Frontiers in immunology}, title = {IFITM protein regulation and functions: Far beyond the fight against viruses}, url = {https://doi.org/10.3389/fimmu.2022.1042368}, volume = {13}, year = {2022} }
TY - JOUR ID - 2251565 AU - Friedlová, Nela - Kokáš, Filip Zavadil - Hupp, Ted R - Vojtěšek, Bořivoj - Nekulová, Marta PY - 2022 TI - IFITM protein regulation and functions: Far beyond the fight against viruses JF - Frontiers in immunology VL - 13 IS - November SP - 1-24 EP - 1-24 PB - Frontiers Media S.A. SN - 16643224 KW - interferon-induced transmembrane proteins KW - tumor progression KW - therapy resistance KW - stem cells KW - immunity KW - tumor immunosurveillance UR - https://doi.org/10.3389/fimmu.2022.1042368 N2 - Interferons (IFNs) are important cytokines that regulate immune responses through the activation of hundreds of genes, including interferon-induced transmembrane proteins (IFITMs). This evolutionarily conserved protein family includes five functionally active homologs in humans. Despite the high sequence homology, IFITMs vary in expression, subcellular localization and function. The initially described adhesive and antiproliferative or pro-oncogenic functions of IFITM proteins were diluted by the discovery of their antiviral properties. The large set of viruses that is inhibited by these proteins is constantly expanding, as are the possible mechanisms of action. In addition to their beneficial antiviral effects, IFITM proteins are often upregulated in a broad spectrum of cancers. IFITM proteins have been linked to most hallmarks of cancer, including tumor cell proliferation, therapeutic resistance, angiogenesis, invasion, and metastasis. Recent studies have described the involvement of IFITM proteins in antitumor immunity. This review summarizes various levels of IFITM protein regulation and the physiological and pathological functions of these proteins, with an emphasis on tumorigenesis and antitumor immunity. ER -
FRIEDLOVÁ, Nela, Filip Zavadil KOKÁŠ, Ted R HUPP, Bořivoj VOJTĚŠEK and Marta NEKULOVÁ. IFITM protein regulation and functions: Far beyond the fight against viruses. \textit{Frontiers in immunology}. Frontiers Media S.A., 2022, vol.~13, November, p.~1-24. ISSN~1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2022.1042368.
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