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@article{2251896,
author = {Franc, Aleš and Vetchý, David and Fülöpová, Nicole},
article_location = {BASEL},
article_number = {11},
doi = {http://dx.doi.org/10.3390/ph15111398},
keywords = {hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology},
language = {eng},
issn = {1424-8247},
journal = {Pharmaceuticals},
title = {Commercially Available Enteric Empty Hard Capsules, Production Technology and Application},
url = {https://www.mdpi.com/1424-8247/15/11/1398},
volume = {15},
year = {2022}
}
TY - JOUR
ID - 2251896
AU - Franc, Aleš - Vetchý, David - Fülöpová, Nicole
PY - 2022
TI - Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
JF - Pharmaceuticals
VL - 15
IS - 11
SP - 1-19
EP - 1-19
PB - MDPI
SN - 14248247
KW - hard capsules
KW - commercial capsules
KW - enteric administration
KW - acid resistance
KW - encapsulation
KW - ECDDT technology
UR - https://www.mdpi.com/1424-8247/15/11/1398
N2 - Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.
ER -
FRANC, Aleš, David VETCHÝ a Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. \textit{Pharmaceuticals}. BASEL: MDPI, roč.~15, č.~11, s.~1-19. ISSN~1424-8247. doi:10.3390/ph15111398. 2022.
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