J 2022

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

FRANC, Aleš, David VETCHÝ a Nicole FÜLÖPOVÁ

Základní údaje

Originální název

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

Autoři

FRANC, Aleš (203 Česká republika, domácí), David VETCHÝ (203 Česká republika, domácí) a Nicole FÜLÖPOVÁ (703 Slovensko, garant, domácí)

Vydání

Pharmaceuticals, BASEL, MDPI, 2022, 1424-8247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14160/22:00128472

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ph15111398

UT WoS

000910840300001

Klíčová slova anglicky

hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 1. 2. 2023 11:13, JUDr. Sabina Krejčiříková

Anotace

V originále

Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.
Zobrazeno: 13. 11. 2024 20:46