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@article{2251896, author = {Franc, Aleš and Vetchý, David and Fülöpová, Nicole}, article_location = {BASEL}, article_number = {11}, doi = {http://dx.doi.org/10.3390/ph15111398}, keywords = {hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology}, language = {eng}, issn = {1424-8247}, journal = {Pharmaceuticals}, title = {Commercially Available Enteric Empty Hard Capsules, Production Technology and Application}, url = {https://www.mdpi.com/1424-8247/15/11/1398}, volume = {15}, year = {2022} }
TY - JOUR ID - 2251896 AU - Franc, Aleš - Vetchý, David - Fülöpová, Nicole PY - 2022 TI - Commercially Available Enteric Empty Hard Capsules, Production Technology and Application JF - Pharmaceuticals VL - 15 IS - 11 SP - 1-19 EP - 1-19 PB - MDPI SN - 14248247 KW - hard capsules KW - commercial capsules KW - enteric administration KW - acid resistance KW - encapsulation KW - ECDDT technology UR - https://www.mdpi.com/1424-8247/15/11/1398 N2 - Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references. ER -
FRANC, Aleš, David VETCHÝ and Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. \textit{Pharmaceuticals}. BASEL: MDPI, 2022, vol.~15, No~11, p.~1-19. ISSN~1424-8247. Available from: https://dx.doi.org/10.3390/ph15111398.
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