Commercially Available Enteric Empty Hard Capsules, Production
Technology and Application

J 2022

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

FRANC, Aleš, David VETCHÝ and Nicole FÜLÖPOVÁ

Basic information

Original name

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

Authors

FRANC, Aleš (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution) and Nicole FÜLÖPOVÁ (703 Slovakia, guarantor, belonging to the institution)

Edition

Pharmaceuticals, BASEL, MDPI, 2022, 1424-8247

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14160/22:00128472

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/ph15111398

UT WoS

000910840300001

Keywords in English

hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology

Abstract

V originále

Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.

Citovat

FRANC, Aleš, David VETCHÝ and Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. Pharmaceuticals. BASEL: MDPI, 2022, vol. 15, No 11, p. 1-19. ISSN 1424-8247. Available from: https://dx.doi.org/10.3390/ph15111398.

@article{2251896,
   author = {Franc, Aleš and Vetchý, David and Fülöpová, Nicole},
   article_location = {BASEL},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/ph15111398},
   keywords = {hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology},
   language = {eng},
   issn = {1424-8247},
   journal = {Pharmaceuticals},
   title = {Commercially Available Enteric Empty Hard Capsules, Production Technology and Application},
   url = {https://www.mdpi.com/1424-8247/15/11/1398},
   volume = {15},
   year = {2022}
}

TY  - JOUR
ID  - 2251896
AU  - Franc, Aleš - Vetchý, David - Fülöpová, Nicole
PY  - 2022
TI  - Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
JF  - Pharmaceuticals
VL  - 15
IS  - 11
SP  - 1-19
EP  - 1-19
PB  - MDPI
SN  - 14248247
KW  - hard capsules
KW  - commercial capsules
KW  - enteric administration
KW  - acid resistance
KW  - encapsulation
KW  - ECDDT technology
UR  - https://www.mdpi.com/1424-8247/15/11/1398
N2  - Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.
ER  -

FRANC, Aleš, David VETCHÝ and Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. \textit{Pharmaceuticals}. BASEL: MDPI, 2022, vol.~15, No~11, p.~1-19. ISSN~1424-8247. Available from: https://dx.doi.org/10.3390/ph15111398.

Detailed Information on Publication Record