Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

FRANC, Aleš, David VETCHÝ and Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. Pharmaceuticals. BASEL: MDPI, 2022, vol. 15, No 11, p. 1-19. ISSN 1424-8247. Available from: https://dx.doi.org/10.3390/ph15111398.

Basic information

• Original name: Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
• Authors: FRANC, Aleš (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution) and Nicole FÜLÖPOVÁ (703 Slovakia, guarantor, belonging to the institution).
• Edition: Pharmaceuticals, BASEL, MDPI, 2022, 1424-8247.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.600
• RIV identification code: RIV/00216224:14160/22:00128472
• Organization unit: Faculty of Pharmacy
• Doi: http://dx.doi.org/10.3390/ph15111398
• UT WoS: 000910840300001
• Keywords in English: hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology
• Tags: rivok, ÚFT
• Tags: International impact, Reviewed

Abstract

Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.