Hypertension treatment in patients with sleep apnea from the
European Sleep Apnea Database (ESADA) cohort - towards
precision medicine

J 2023

Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine

SVEDMYR, Sven, Jan HEDNER, Maria Rosaria BONSIGNORE, Carolina LOMBARDI, Gianfranco PARATI et. al.

Basic information

Original name

Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine

Authors

SVEDMYR, Sven (guarantor), Jan HEDNER, Maria Rosaria BONSIGNORE, Carolina LOMBARDI, Gianfranco PARATI, Ondřej LUDKA (203 Czech Republic, belonging to the institution), Ding ZOU and Ludger GROTE

Edition

Journal of Sleep Research, HOBOKEN, WILEY, 2023, 0962-1105

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.400 in 2022

RIV identification code

RIV/00216224:14110/23:00130273

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/jsr.13811

UT WoS

000899297400001

Keywords in English

antihypertensive treatment; beta-blocker; blood pressure control; diuretic; hypertension; obstructive sleep apnea

Abstract

V originále

We recruited 5,970 patients with hypertension with obstructive sleep apnea (OSA) on current antihypertensive treatment from the European Sleep Apnea Database (ESADA) cohort. The group was subdivided into those receiving monotherapy (n = 3,594) and those receiving dual combined therapy (n = 2,376). We studied how major OSA confounders like age, gender, and body mass index as well as the degree of sleep apnea modified office systolic and diastolic blood pressure. Beta-blockers alone or in combination with a diuretic were compared with other antihypertensive drug classes. Monotherapy with beta-blocker was associated with lower systolic blood pressure, particularly in non-obese middle-aged males with hypertension. Conversely, the combination of a beta-blocker and a diuretic was associated with lower systolic and diastolic blood pressure in patients with hypertension with moderate-severe OSA. Systolic blood pressure was better controlled in female patients using this combined treatment. Our cross-sectional data suggest that specific clinical characteristics and type of antihypertensive medication influence the degree of blood pressure control in patients with hypertension with OSA. Controlled trials are warranted.

Citovat

SVEDMYR, Sven, Jan HEDNER, Maria Rosaria BONSIGNORE, Carolina LOMBARDI, Gianfranco PARATI, Ondřej LUDKA, Ding ZOU and Ludger GROTE. Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine. Journal of Sleep Research. HOBOKEN: WILEY, 2023, vol. 32, No 4, p. 1-7. ISSN 0962-1105. Available from: https://dx.doi.org/10.1111/jsr.13811.

@article{2251946,
   author = {Svedmyr, Sven and Hedner, Jan and Bonsignore, Maria Rosaria and Lombardi, Carolina and Parati, Gianfranco and Ludka, Ondřej and Zou, Ding and Grote, Ludger},
   article_location = {HOBOKEN},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/jsr.13811},
   keywords = {antihypertensive treatment; beta-blocker; blood pressure control; diuretic; hypertension; obstructive sleep apnea},
   language = {eng},
   issn = {0962-1105},
   journal = {Journal of Sleep Research},
   title = {Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/jsr.13811},
   volume = {32},
   year = {2023}
}

TY  - JOUR
ID  - 2251946
AU  - Svedmyr, Sven - Hedner, Jan - Bonsignore, Maria Rosaria - Lombardi, Carolina - Parati, Gianfranco - Ludka, Ondřej - Zou, Ding - Grote, Ludger
PY  - 2023
TI  - Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine
JF  - Journal of Sleep Research
VL  - 32
IS  - 4
SP  - 1-7
EP  - 1-7
PB  - WILEY
SN  - 09621105
KW  - antihypertensive treatment
KW  - beta-blocker
KW  - blood pressure control
KW  - diuretic
KW  - hypertension
KW  - obstructive sleep apnea
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jsr.13811
N2  - We recruited 5,970 patients with hypertension with obstructive sleep apnea (OSA) on current antihypertensive treatment from the European Sleep Apnea Database (ESADA) cohort. The group was subdivided into those receiving monotherapy (n = 3,594) and those receiving dual combined therapy (n = 2,376). We studied how major OSA confounders like age, gender, and body mass index as well as the degree of sleep apnea modified office systolic and diastolic blood pressure. Beta-blockers alone or in combination with a diuretic were compared with other antihypertensive drug classes. Monotherapy with beta-blocker was associated with lower systolic blood pressure, particularly in non-obese middle-aged males with hypertension. Conversely, the combination of a beta-blocker and a diuretic was associated with lower systolic and diastolic blood pressure in patients with hypertension with moderate-severe OSA. Systolic blood pressure was better controlled in female patients using this combined treatment. Our cross-sectional data suggest that specific clinical characteristics and type of antihypertensive medication influence the degree of blood pressure control in patients with hypertension with OSA. Controlled trials are warranted.
ER  -

SVEDMYR, Sven, Jan HEDNER, Maria Rosaria BONSIGNORE, Carolina LOMBARDI, Gianfranco PARATI, Ondřej LUDKA, Ding ZOU and Ludger GROTE. Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine. \textit{Journal of Sleep Research}. HOBOKEN: WILEY, 2023, vol.~32, No~4, p.~1-7. ISSN~0962-1105. Available from: https://dx.doi.org/10.1111/jsr.13811.

Detailed Information on Publication Record