| NOURI, Aria, Enrico TESSITORE, Granit MOLLIQAJ, Torstein MELING, Karl SCHALLER, Hiroaki NAKASHIMA, Yasutsugu YUKAWA, Josef BEDNAŘÍK, Allan R MARTIN, Peter VAJKOCZY, Joseph S CHENG, Brian K KWON, Shekar N KURPAD, Michael G FEHLINGS, James S HARROP, Bizhan AARABI, Vafa RAHIMI-MOVAGHAR, James D GUEST, Benjamin M DAVIES, Mark R N KOTTER and Jefferson R WILSON. Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]. GLOBAL SPINE JOURNAL. LONDON: SAGE PUBLICATIONS LTD, 2022, vol. 12, 1_SUPPL, p. "39S"-"54S", 16 pp. ISSN 2192-5682. Available from: https://dx.doi.org/10.1177/21925682211036071. |
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@article{2251953,
author = {Nouri, Aria and Tessitore, Enrico and Molliqaj, Granit and Meling, Torstein and Schaller, Karl and Nakashima, Hiroaki and Yukawa, Yasutsugu and Bednařík, Josef and Martin, Allan R and Vajkoczy, Peter and Cheng, Joseph S and Kwon, Brian K and Kurpad, Shekar N and Fehlings, Michael G and Harrop, James S and Aarabi, Bizhan and RahimiandMovaghar, Vafa and Guest, James D and Davies, Benjamin M and Kotter, Mark R N and Wilson, Jefferson R},
article_location = {LONDON},
article_number = {1_SUPPL},
doi = {http://dx.doi.org/10.1177/21925682211036071},
keywords = {cervical spondylotic myelopathy (CSM); cord compression; ossification of the posterior longitudinal ligament (OPLL); progression; risk factors},
language = {eng},
issn = {2192-5682},
journal = {GLOBAL SPINE JOURNAL},
title = {Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]},
url = {https://journals.sagepub.com/doi/10.1177/21925682211036071},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2251953
AU - Nouri, Aria - Tessitore, Enrico - Molliqaj, Granit - Meling, Torstein - Schaller, Karl - Nakashima, Hiroaki - Yukawa, Yasutsugu - Bednařík, Josef - Martin, Allan R - Vajkoczy, Peter - Cheng, Joseph S - Kwon, Brian K - Kurpad, Shekar N - Fehlings, Michael G - Harrop, James S - Aarabi, Bizhan - Rahimi-Movaghar, Vafa - Guest, James D - Davies, Benjamin M - Kotter, Mark R N - Wilson, Jefferson R
PY - 2022
TI - Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]
JF - GLOBAL SPINE JOURNAL
VL - 12
IS - 1_SUPPL
SP - "39S"-"54S"
EP - "39S"-"54S"
PB - SAGE PUBLICATIONS LTD
SN - 21925682
KW - cervical spondylotic myelopathy (CSM)
KW - cord compression
KW - ossification of the posterior longitudinal ligament (OPLL)
KW - progression
KW - risk factors
UR - https://journals.sagepub.com/doi/10.1177/21925682211036071
N2 - Study Design: Narrative review. Objectives: To discuss the current understanding of the natural history of degenerative cervical myelopathy (DCM). Methods: Literature review summarizing current evidence pertaining to the natural history and risk factors of DCM. Results: DCM is a common condition in which progressive arthritic disease of the cervical spine leads to spinal cord compression resulting in a constellation of neurological symptoms, in particular upper extremity dysfunction and gait impairment. Anatomical factors including cord-canal mismatch, congenitally fused vertebrae and genetic factors may increase individuals' risk for DCM development. Non-myelopathic spinal cord compression (NMSCC) is a common phenomenon with a prevalence of 24.2% in the healthy population, and 35.3% among individuals >60 years of age. Clinical radiculopathy and/or electrophysiological signs of cervical cord dysfunction appear to be risk factors for myelopathy development. Radiological progression of incidental Ossification of the Posterior Longitudinal Ligament (OPLL) is estimated at 18.3% over 81-months and development of myelopathy ranges between 0-61.5% (follow-up ranging from 40 to 124 months between studies) among studies. In patients with symptomatic DCM undergoing non-operative treatment, 20-62% will experience neurological deterioration within 3-6 years. Conclusion: Current estimates surrounding the natural history of DCM, particularly those individuals with mild or minimal impairment, lack precision. Clear predictors of clinical deterioration for those treated with non-operative care are yet to be identified. Future studies are needed on this topic to help improve treatment counseling and clinical prognostication.
ER -
NOURI, Aria, Enrico TESSITORE, Granit MOLLIQAJ, Torstein MELING, Karl SCHALLER, Hiroaki NAKASHIMA, Yasutsugu YUKAWA, Josef BEDNAŘÍK, Allan R MARTIN, Peter VAJKOCZY, Joseph S CHENG, Brian K KWON, Shekar N KURPAD, Michael G FEHLINGS, James S HARROP, Bizhan AARABI, Vafa RAHIMI-MOVAGHAR, James D GUEST, Benjamin M DAVIES, Mark R N KOTTER and Jefferson R WILSON. Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]. \textit{GLOBAL SPINE JOURNAL}. LONDON: SAGE PUBLICATIONS LTD, 2022, vol.~12, 1\_{}SUPPL, p.~''39S''-''54S'', 16 pp. ISSN~2192-5682. Available from: https://dx.doi.org/10.1177/21925682211036071.
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