Degenerative Cervical Myelopathy: Development and Natural
History [AO Spine RECODE-DCM Research Priority Number 2]

J 2022

Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]

NOURI, Aria, Enrico TESSITORE, Granit MOLLIQAJ, Torstein MELING, Karl SCHALLER et. al.

Basic information

Original name

Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]

Authors

NOURI, Aria (guarantor), Enrico TESSITORE, Granit MOLLIQAJ, Torstein MELING, Karl SCHALLER, Hiroaki NAKASHIMA, Yasutsugu YUKAWA, Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Allan R MARTIN, Peter VAJKOCZY, Joseph S CHENG, Brian K KWON, Shekar N KURPAD, Michael G FEHLINGS, James S HARROP, Bizhan AARABI, Vafa RAHIMI-MOVAGHAR, James D GUEST, Benjamin M DAVIES, Mark R N KOTTER and Jefferson R WILSON

Edition

GLOBAL SPINE JOURNAL, LONDON, SAGE PUBLICATIONS LTD, 2022, 2192-5682

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.400

RIV identification code

RIV/00216224:14110/22:00129737

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1177/21925682211036071

UT WoS

000758327200005

Keywords in English

cervical spondylotic myelopathy (CSM); cord compression; ossification of the posterior longitudinal ligament (OPLL); progression; risk factors

Abstract

V originále

Study Design: Narrative review. Objectives: To discuss the current understanding of the natural history of degenerative cervical myelopathy (DCM). Methods: Literature review summarizing current evidence pertaining to the natural history and risk factors of DCM. Results: DCM is a common condition in which progressive arthritic disease of the cervical spine leads to spinal cord compression resulting in a constellation of neurological symptoms, in particular upper extremity dysfunction and gait impairment. Anatomical factors including cord-canal mismatch, congenitally fused vertebrae and genetic factors may increase individuals' risk for DCM development. Non-myelopathic spinal cord compression (NMSCC) is a common phenomenon with a prevalence of 24.2% in the healthy population, and 35.3% among individuals >60 years of age. Clinical radiculopathy and/or electrophysiological signs of cervical cord dysfunction appear to be risk factors for myelopathy development. Radiological progression of incidental Ossification of the Posterior Longitudinal Ligament (OPLL) is estimated at 18.3% over 81-months and development of myelopathy ranges between 0-61.5% (follow-up ranging from 40 to 124 months between studies) among studies. In patients with symptomatic DCM undergoing non-operative treatment, 20-62% will experience neurological deterioration within 3-6 years. Conclusion: Current estimates surrounding the natural history of DCM, particularly those individuals with mild or minimal impairment, lack precision. Clear predictors of clinical deterioration for those treated with non-operative care are yet to be identified. Future studies are needed on this topic to help improve treatment counseling and clinical prognostication.

Links

NV18-04-00159, research and development project

Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministry of Health of the CR

Citovat

NOURI, Aria, Enrico TESSITORE, Granit MOLLIQAJ, Torstein MELING, Karl SCHALLER, Hiroaki NAKASHIMA, Yasutsugu YUKAWA, Josef BEDNAŘÍK, Allan R MARTIN, Peter VAJKOCZY, Joseph S CHENG, Brian K KWON, Shekar N KURPAD, Michael G FEHLINGS, James S HARROP, Bizhan AARABI, Vafa RAHIMI-MOVAGHAR, James D GUEST, Benjamin M DAVIES, Mark R N KOTTER and Jefferson R WILSON. Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]. GLOBAL SPINE JOURNAL. LONDON: SAGE PUBLICATIONS LTD, 2022, vol. 12, 1_SUPPL, p. "39S"-"54S", 16 pp. ISSN 2192-5682. Available from: https://dx.doi.org/10.1177/21925682211036071.

@article{2251953,
   author = {Nouri, Aria and Tessitore, Enrico and Molliqaj, Granit and Meling, Torstein and Schaller, Karl and Nakashima, Hiroaki and Yukawa, Yasutsugu and Bednařík, Josef and Martin, Allan R and Vajkoczy, Peter and Cheng, Joseph S and Kwon, Brian K and Kurpad, Shekar N and Fehlings, Michael G and Harrop, James S and Aarabi, Bizhan and RahimiandMovaghar, Vafa and Guest, James D and Davies, Benjamin M and Kotter, Mark R N and Wilson, Jefferson R},
   article_location = {LONDON},
   article_number = {1_SUPPL},
   doi = {http://dx.doi.org/10.1177/21925682211036071},
   keywords = {cervical spondylotic myelopathy (CSM); cord compression; ossification of the posterior longitudinal ligament (OPLL); progression; risk factors},
   language = {eng},
   issn = {2192-5682},
   journal = {GLOBAL SPINE JOURNAL},
   title = {Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]},
   url = {https://journals.sagepub.com/doi/10.1177/21925682211036071},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2251953
AU  - Nouri, Aria - Tessitore, Enrico - Molliqaj, Granit - Meling, Torstein - Schaller, Karl - Nakashima, Hiroaki - Yukawa, Yasutsugu - Bednařík, Josef - Martin, Allan R - Vajkoczy, Peter - Cheng, Joseph S - Kwon, Brian K - Kurpad, Shekar N - Fehlings, Michael G - Harrop, James S - Aarabi, Bizhan - Rahimi-Movaghar, Vafa - Guest, James D - Davies, Benjamin M - Kotter, Mark R N - Wilson, Jefferson R
PY  - 2022
TI  - Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]
JF  - GLOBAL SPINE JOURNAL
VL  - 12
IS  - 1_SUPPL
SP  - "39S"-"54S"
EP  - "39S"-"54S"
PB  - SAGE PUBLICATIONS LTD
SN  - 21925682
KW  - cervical spondylotic myelopathy (CSM)
KW  - cord compression
KW  - ossification of the posterior longitudinal ligament (OPLL)
KW  - progression
KW  - risk factors
UR  - https://journals.sagepub.com/doi/10.1177/21925682211036071
N2  - Study Design: Narrative review. Objectives: To discuss the current understanding of the natural history of degenerative cervical myelopathy (DCM). Methods: Literature review summarizing current evidence pertaining to the natural history and risk factors of DCM. Results: DCM is a common condition in which progressive arthritic disease of the cervical spine leads to spinal cord compression resulting in a constellation of neurological symptoms, in particular upper extremity dysfunction and gait impairment. Anatomical factors including cord-canal mismatch, congenitally fused vertebrae and genetic factors may increase individuals' risk for DCM development. Non-myelopathic spinal cord compression (NMSCC) is a common phenomenon with a prevalence of 24.2% in the healthy population, and 35.3% among individuals >60 years of age. Clinical radiculopathy and/or electrophysiological signs of cervical cord dysfunction appear to be risk factors for myelopathy development. Radiological progression of incidental Ossification of the Posterior Longitudinal Ligament (OPLL) is estimated at 18.3% over 81-months and development of myelopathy ranges between 0-61.5% (follow-up ranging from 40 to 124 months between studies) among studies. In patients with symptomatic DCM undergoing non-operative treatment, 20-62% will experience neurological deterioration within 3-6 years. Conclusion: Current estimates surrounding the natural history of DCM, particularly those individuals with mild or minimal impairment, lack precision. Clear predictors of clinical deterioration for those treated with non-operative care are yet to be identified. Future studies are needed on this topic to help improve treatment counseling and clinical prognostication.
ER  -

NOURI, Aria, Enrico TESSITORE, Granit MOLLIQAJ, Torstein MELING, Karl SCHALLER, Hiroaki NAKASHIMA, Yasutsugu YUKAWA, Josef BEDNAŘÍK, Allan R MARTIN, Peter VAJKOCZY, Joseph S CHENG, Brian K KWON, Shekar N KURPAD, Michael G FEHLINGS, James S HARROP, Bizhan AARABI, Vafa RAHIMI-MOVAGHAR, James D GUEST, Benjamin M DAVIES, Mark R N KOTTER and Jefferson R WILSON. Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]. \textit{GLOBAL SPINE JOURNAL}. LONDON: SAGE PUBLICATIONS LTD, 2022, vol.~12, 1\_{}SUPPL, p.~''39S''-''54S'', 16 pp. ISSN~2192-5682. Available from: https://dx.doi.org/10.1177/21925682211036071.

Detailed Information on Publication Record