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@article{2252345,
author = {Hajji, Khadija and Sedmík, Jiří and Cherian, Anna and Amoruso, Damiano and Keegan, Liam and O'Connell, Mary Anne},
article_location = {Cold Spring Harbor},
article_number = {10},
doi = {http://dx.doi.org/10.1261/rna.079266.122},
keywords = {ADAR; ADARB1; dsRNA; recoding RNA editing; neurons},
language = {eng},
issn = {1355-8382},
journal = {RNA},
title = {ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations},
url = {https://rnajournal.cshlp.org/content/28/10/1281},
volume = {28},
year = {2022}
}
TY - JOUR
ID - 2252345
AU - Hajji, Khadija - Sedmík, Jiří - Cherian, Anna - Amoruso, Damiano - Keegan, Liam - O'Connell, Mary Anne
PY - 2022
TI - ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations
JF - RNA
VL - 28
IS - 10
SP - 1281-1297
EP - 1281-1297
PB - Cold Spring Harbor Laboratory Press
SN - 13558382
KW - ADAR
KW - ADARB1
KW - dsRNA
KW - recoding RNA editing
KW - neurons
UR - https://rnajournal.cshlp.org/content/28/10/1281
N2 - The adenosine deaminase acting on RNA (ADAR) enzymes are essential for neuronal function and innate immune control. ADAR1 RNA editing prevents aberrant activation of antiviral dsRNA sensors through editing of long, double-stranded RNAs (dsRNAs). In this review, we focus on the ADAR2 proteins involved in the efficient, highly site-specific RNA editing to recode open reading frames first discovered in the GRIA2 transcript encoding the key GLUA2 subunit of AMPA receptors; ADAR1 proteins also edit many of these sites. We summarize the history of ADAR2 protein research and give an up-to-date review of ADAR2 structural studies, human ADARBI (ADAR2) mutants causing severe infant seizures, and mouse disease models. Structural studies on ADARs and their RNA substrates facilitate current efforts to develop ADAR RNA editing gene therapy to edit disease-causing single nucleotide polymorphisms (SNPs). Artificial ADAR guide RNAs are being developed to retarget ADAR RNA editing to new target transcripts in order to correct SNP mutations in them at the RNA level. Site-specific RNA editing has been expanded to recode hundreds of sites in CNS transcripts in Drosophila and cephalopods. In Drosophila and C. elegans, ADAR RNA editing also suppresses responses to self dsRNA.
ER -
HAJJI, Khadija, Jiří SEDMÍK, Anna CHERIAN, Damiano AMORUSO, Liam KEEGAN and Mary Anne O'CONNELL. ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations. \textit{RNA}. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2022, vol.~28, No~10, p.~1281-1297. ISSN~1355-8382. Available from: https://dx.doi.org/10.1261/rna.079266.122.
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