A Brief Physiology of Ion Balance in Mammal Cardiomyocytes

D 2022

A Brief Physiology of Ion Balance in Mammal Cardiomyocytes

NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ et. al.

Basic information

Original name

A Brief Physiology of Ion Balance in Mammal Cardiomyocytes

Authors

NACHTNEBL, Luboš (203 Czech Republic, guarantor, belonging to the institution), Petr FILIPENSKÝ (203 Czech Republic, belonging to the institution), Magda KRECHLEROVÁ (203 Czech Republic, belonging to the institution), Helena BEDÁŇOVÁ (203 Czech Republic, belonging to the institution), Alena SEDLÁKOVÁ (203 Czech Republic, belonging to the institution), Adam VAJČNER (203 Czech Republic, belonging to the institution), Michal POHANKA (203 Czech Republic, belonging to the institution) and Petr DOBŠÁK (203 Czech Republic, belonging to the institution)

Edition

Brno, Noninvasive methods in cardiology 2022, p. 99-108, 10 pp. 2022

Publisher

Masaryk University Press

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14110/22:00128529

Organization unit

Faculty of Medicine

ISBN

978-80-280-0170-4

Keywords in English

Ion Balance; Mammal Cardiomyocytes

Abstract

V originále

The muscle cells (cardiomyocytes) that make up all of the heart muscle contract in a repetitive, organized and adapted way in order to ensure the final function of circulatory support. The coordination of the contractile function is ensured thanks to the syncitium structure of the cardiac tissue which allows the propagation of the electrical activity from one cardiac cell to another. This electrical activity translates into an action potential (AP) which represents the result of a cascade of ion transfers (entry of Na+ and Ca++ ions, exit of K+ ions), largely depending on the variations in permeability of the sarcolemma and succeeding from the diastolic potential. The latter, located between -80 and -90 mV, depends on the characteristics of the sarcolemma which, at rest, is almost exclusively permeable to K+ , and on the variations in ionic concentrations (Na+ and K+ ) on either side of this membrane. However, in diastole, the sarcolemma is slightly permeable to Na+ and the concentration gradients are maintained thanks to active transport ensured by an electrogenic ATP-dependent Na+ /K+ membrane pump.

Citovat

NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ, Adam VAJČNER, Michal POHANKA and Petr DOBŠÁK. A Brief Physiology of Ion Balance in Mammal Cardiomyocytes. In Cornélissen G., Siegelová J., Dobšák P. Noninvasive methods in cardiology 2022. Brno: Masaryk University Press, 2022, p. 99-108. ISBN 978-80-280-0170-4.

@inproceedings{2252414,
   author = {Nachtnebl, Luboš and Filipenský, Petr and Krechlerová, Magda and Bedáňová, Helena and Sedláková, Alena and Vajčner, Adam and Pohanka, Michal and Dobšák, Petr},
   address = {Brno},
   booktitle = {Noninvasive methods in cardiology 2022},
   editor = {Cornélissen G., Siegelová J., Dobšák P.},
   keywords = {Ion Balance; Mammal Cardiomyocytes},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-280-0170-4},
   pages = {99-108},
   publisher = {Masaryk University Press},
   title = {A Brief Physiology of Ion Balance in Mammal Cardiomyocytes},
   url = {https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf},
   year = {2022}
}

TY  - JOUR
ID  - 2252414
AU  - Nachtnebl, Luboš - Filipenský, Petr - Krechlerová, Magda - Bedáňová, Helena - Sedláková, Alena - Vajčner, Adam - Pohanka, Michal - Dobšák, Petr
PY  - 2022
TI  - A Brief Physiology of Ion Balance in Mammal Cardiomyocytes
PB  - Masaryk University Press
CY  - Brno
SN  - 9788028001704
KW  - Ion Balance
KW  - Mammal Cardiomyocytes
UR  - https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf
N2  - The muscle cells (cardiomyocytes) that make up all of the heart muscle contract in a repetitive, organized and adapted way in order to ensure the final function of circulatory support. The coordination of the contractile function is ensured thanks to the syncitium structure of the cardiac tissue which allows the propagation of the electrical activity from one cardiac cell to another. This electrical activity translates into an action potential (AP) which represents the result of a cascade of ion transfers (entry of Na+ and Ca++ ions, exit of K+ ions), largely depending on the variations in permeability of the sarcolemma and succeeding from the diastolic potential. The latter, located between -80 and -90 mV, depends on the characteristics of the sarcolemma which, at rest, is almost exclusively permeable to K+ , and on the variations in ionic concentrations (Na+ and K+ ) on either side of this membrane. However, in diastole, the sarcolemma is slightly permeable to Na+ and the concentration gradients are maintained thanks to active transport ensured by an electrogenic ATP-dependent Na+ /K+ membrane pump.
ER  -

NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ, Adam VAJČNER, Michal POHANKA and Petr DOBŠÁK. A Brief Physiology of Ion Balance in Mammal Cardiomyocytes. In Cornélissen G., Siegelová J., Dobšák P. \textit{Noninvasive methods in cardiology 2022}. Brno: Masaryk University Press, 2022, p.~99-108. ISBN~978-80-280-0170-4.

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