Destabilization of Ionic Transport Systems in Cardiomyocytes
During Hypoxia and Ischemia

D 2022

Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia

NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ et. al.

Basic information

Original name

Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia

Authors

NACHTNEBL, Luboš (203 Czech Republic, guarantor, belonging to the institution), Petr FILIPENSKÝ (203 Czech Republic, belonging to the institution), Magda KRECHLEROVÁ (203 Czech Republic, belonging to the institution), Helena BEDÁŇOVÁ (203 Czech Republic, belonging to the institution), Alena SEDLÁKOVÁ (203 Czech Republic, belonging to the institution), Adam VAJČNER (203 Czech Republic, belonging to the institution), Michal POHANKA (203 Czech Republic, belonging to the institution) and Petr DOBŠÁK (203 Czech Republic, belonging to the institution)

Edition

Brno, Masaryk University Press, p. 109-119, 11 pp. 2022

Publisher

Masaryk University Press

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14110/22:00128530

Organization unit

Faculty of Medicine

ISBN

978-80-280-0170-4

Keywords in English

Ionic Transport Systems; Cardiomyocytes During Hypoxia and Ischemia

Abstract

V originále

In 1994, one hundred and thirty-six years after the introduction of the term “ischemia” by Virchow, the journal Cardiovascular Research conducted a survey among eminent cardiologists to find out “their” definition of myocardial ischemia (Hearse, 1994). The results showed the responses ranged from 3 to 404 words (!). This clearly shows that a generally accepted definition does not currently exist. However, it is undisputed that ischemia is necessarily associated with changes in the energy metabolism and ionic disturbances of the myocardium. It is difficult to study ischemia experimentally and in particular in isolated muscle preparations. For this reason, many studies concerning the effects of ischemia on contractile function have used experimental protocols that reproduce only some of the metabolic, ionic and mechanical aspects of ischemia. The most used models are hypoxia or anoxia, based on partial or total suppression of oxygen (O2 ) in the perfusion medium (replacement of O2 by nitrogen or application of a reducing agent, such as sodium dithionate), or even on the use of blockers of oxidative phosphorylation (OP) such as cyanide (CN).

Citovat

NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ, Adam VAJČNER, Michal POHANKA and Petr DOBŠÁK. Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia. In Cornélissen G., Siegelová J., Dobšák P. Masaryk University Press. Brno: Masaryk University Press, 2022, p. 109-119. ISBN 978-80-280-0170-4.

@inproceedings{2252416,
   author = {Nachtnebl, Luboš and Filipenský, Petr and Krechlerová, Magda and Bedáňová, Helena and Sedláková, Alena and Vajčner, Adam and Pohanka, Michal and Dobšák, Petr},
   address = {Brno},
   booktitle = {Masaryk University Press},
   editor = {Cornélissen G., Siegelová J., Dobšák P.},
   keywords = {Ionic Transport Systems; Cardiomyocytes During Hypoxia and Ischemia},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-280-0170-4},
   pages = {109-119},
   publisher = {Masaryk University Press},
   title = {Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia},
   url = {https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf},
   year = {2022}
}

TY  - JOUR
ID  - 2252416
AU  - Nachtnebl, Luboš - Filipenský, Petr - Krechlerová, Magda - Bedáňová, Helena - Sedláková, Alena - Vajčner, Adam - Pohanka, Michal - Dobšák, Petr
PY  - 2022
TI  - Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia
PB  - Masaryk University Press
CY  - Brno
SN  - 9788028001704
KW  - Ionic Transport Systems
KW  - Cardiomyocytes During Hypoxia and Ischemia
UR  - https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf
N2  - In 1994, one hundred and thirty-six years after the introduction of the term “ischemia” by Virchow, the journal Cardiovascular Research conducted a survey among eminent cardiologists to find out “their” definition of myocardial ischemia (Hearse, 1994). The results showed the responses ranged from 3 to 404 words (!). This clearly shows that a generally accepted definition does not currently exist. However, it is undisputed that ischemia is necessarily associated with changes in the energy metabolism and ionic disturbances of the myocardium. It is difficult to study ischemia experimentally and in particular in isolated muscle preparations. For this reason, many studies concerning the effects of ischemia on contractile function have used experimental protocols that reproduce only some of the metabolic, ionic and mechanical aspects of ischemia. The most used models are hypoxia or anoxia, based on partial or total suppression of oxygen (O2 ) in the perfusion medium (replacement of O2 by nitrogen or application of a reducing agent, such as sodium dithionate), or even on the use of blockers of oxidative phosphorylation (OP) such as cyanide (CN).
ER  -

NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ, Adam VAJČNER, Michal POHANKA and Petr DOBŠÁK. Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia. In Cornélissen G., Siegelová J., Dobšák P. \textit{Masaryk University Press}. Brno: Masaryk University Press, 2022, p.~109-119. ISBN~978-80-280-0170-4.

Detailed Information on Publication Record