CHOCHOLOVÁ, Eva, Eva DROZDOVÁ, Dana FIALOVÁ, Pavel ROUDNICKÝ, Zbyněk ZDRÁHAL, Barbora ZWINSOVÁ, Kateřina NOVOTNÁ, Filip PARDY, Jakub HYNŠT, Marek PEŠKA, Antonín ZŮBEK, Kateřina MRÁZOVÁ, Vladislav KRZYŽÁNEK, Michael DOUBEK and Šárka POSPÍŠILOVÁ. Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel. Folia Mendeliana : supplementum ad Acta Musei Moraviae. Moravian Museum Brno, 2022, vol. 58, No 1, p. 57-61. ISSN 0085-0748.
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Basic information
Original name Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
Authors CHOCHOLOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Eva DROZDOVÁ (203 Czech Republic, belonging to the institution), Dana FIALOVÁ (203 Czech Republic, belonging to the institution), Pavel ROUDNICKÝ (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution), Barbora ZWINSOVÁ (203 Czech Republic, belonging to the institution), Kateřina NOVOTNÁ (203 Czech Republic, belonging to the institution), Filip PARDY (203 Czech Republic, belonging to the institution), Jakub HYNŠT (203 Czech Republic, belonging to the institution), Marek PEŠKA (203 Czech Republic), Antonín ZŮBEK (203 Czech Republic), Kateřina MRÁZOVÁ, Vladislav KRZYŽÁNEK (203 Czech Republic), Michael DOUBEK (203 Czech Republic, belonging to the institution) and Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution).
Edition Folia Mendeliana : supplementum ad Acta Musei Moraviae, Moravian Museum Brno, 2022, 0085-0748.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14310/22:00128536
Organization unit Faculty of Science
Keywords in English Gregor Johann Mendel; oral microbiome; dental calculus; palaeoproteomics; palaeogenomics; periodontitis
Tags International impact
Changed by Changed by: Mgr. Eva Chocholová, učo 423026. Changed: 27/4/2023 16:43.
Abstract
As part of the interdisciplinary research of abbot and founder of genetics, Gregor Johann Mendel, his dental calculus was sampled to gain insight into his health that could not be obtained by mere genome sequencing. A total of 469 proteins were found after filtering, including proteins related to immunity and oral health. Multiple oral species connected to dental pathology such as periodontitis were confirmed based on both DNA and proteins, originating from Porphyromonas gingivalis, Tannerella forsythia, or Treponema denticola. High abundance of Clostridiales DNA was confirmed, in agreement with mummification by saponification.
Links
LM2015085, research and development projectName: CERIT Scientific Cloud (Acronym: CERIT-SC)
Investor: Ministry of Education, Youth and Sports of the CR, CERIT Scientific Cloud
LM2018127, research and development projectName: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)
Investor: Ministry of Education, Youth and Sports of the CR
LM2018132, research and development projectName: Národní centrum lékařské genomiky (Acronym: NCLG)
Investor: Ministry of Education, Youth and Sports of the CR, National Center for Medical Genomics
LM2018140, research and development projectName: e-Infrastruktura CZ (Acronym: e-INFRA CZ)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/1325/2021, interní kód MUName: Podpora výzkumné činnosti studentů molekulární biologie a genetiky 10 (Acronym: MBG10)
Investor: Masaryk University
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