Metagenomic and proteomic analysis of dental calculus of abbot
Gregor Johann Mendel

J 2022

Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel

CHOCHOLOVÁ, Eva, Eva DROZDOVÁ, Dana FIALOVÁ, Pavel ROUDNICKÝ, Zbyněk ZDRÁHAL et. al.

Basic information

Original name

Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel

Authors

CHOCHOLOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Eva DROZDOVÁ (203 Czech Republic, belonging to the institution), Dana FIALOVÁ (203 Czech Republic, belonging to the institution), Pavel ROUDNICKÝ (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution), Barbora ZWINSOVÁ (203 Czech Republic, belonging to the institution), Kateřina NOVOTNÁ (203 Czech Republic, belonging to the institution), Filip PARDY (203 Czech Republic, belonging to the institution), Jakub HYNŠT (203 Czech Republic, belonging to the institution), Marek PEŠKA (203 Czech Republic), Antonín ZŮBEK (203 Czech Republic), Kateřina MRÁZOVÁ, Vladislav KRZYŽÁNEK (203 Czech Republic), Michael DOUBEK (203 Czech Republic, belonging to the institution) and Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution)

Edition

Folia Mendeliana : supplementum ad Acta Musei Moraviae, Moravian Museum Brno, 2022, 0085-0748

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14310/22:00128536

Organization unit

Faculty of Science

Keywords in English

Gregor Johann Mendel; oral microbiome; dental calculus; palaeoproteomics; palaeogenomics; periodontitis

Abstract

V originále

As part of the interdisciplinary research of abbot and founder of genetics, Gregor Johann Mendel, his dental calculus was sampled to gain insight into his health that could not be obtained by mere genome sequencing. A total of 469 proteins were found after filtering, including proteins related to immunity and oral health. Multiple oral species connected to dental pathology such as periodontitis were confirmed based on both DNA and proteins, originating from Porphyromonas gingivalis, Tannerella forsythia, or Treponema denticola. High abundance of Clostridiales DNA was confirmed, in agreement with mummification by saponification.

Links

LM2015085, research and development project

Name: CERIT Scientific Cloud (Acronym: CERIT-SC)

Investor: Ministry of Education, Youth and Sports of the CR, CERIT Scientific Cloud

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

LM2018132, research and development project

Name: Národní centrum lékařské genomiky (Acronym: NCLG)

Investor: Ministry of Education, Youth and Sports of the CR, National Center for Medical Genomics

LM2018140, research and development project

Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1325/2021, interní kód MU

Name: Podpora výzkumné činnosti studentů molekulární biologie a genetiky 10 (Acronym: MBG10)

Investor: Masaryk University

Citovat

CHOCHOLOVÁ, Eva, Eva DROZDOVÁ, Dana FIALOVÁ, Pavel ROUDNICKÝ, Zbyněk ZDRÁHAL, Barbora ZWINSOVÁ, Kateřina NOVOTNÁ, Filip PARDY, Jakub HYNŠT, Marek PEŠKA, Antonín ZŮBEK, Kateřina MRÁZOVÁ, Vladislav KRZYŽÁNEK, Michael DOUBEK and Šárka POSPÍŠILOVÁ. Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel. Folia Mendeliana : supplementum ad Acta Musei Moraviae. Moravian Museum Brno, 2022, vol. 58, No 1, p. 57-61. ISSN 0085-0748.

@article{2252433,
   author = {Chocholová, Eva and Drozdová, Eva and Fialová, Dana and Roudnický, Pavel and Zdráhal, Zbyněk and Zwinsová, Barbora and Novotná, Kateřina and Pardy, Filip and Hynšt, Jakub and Peška, Marek and Zůbek, Antonín and Mrázová, Kateřina and Krzyžánek, Vladislav and Doubek, Michael and Pospíšilová, Šárka},
   article_number = {1},
   keywords = {Gregor Johann Mendel; oral microbiome; dental calculus; palaeoproteomics; palaeogenomics; periodontitis},
   language = {eng},
   issn = {0085-0748},
   journal = {Folia Mendeliana : supplementum ad Acta Musei Moraviae},
   title = {Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel},
   url = {http://www.mzm.cz/e-shop?ai%5Baction%5D=list&ai%5Bcontroller%5D=Catalog&ai%5Bf_catid%5D=23&ai%5Bf_name%5D=Folia-Mendeliana},
   volume = {58},
   year = {2022}
}

TY  - JOUR
ID  - 2252433
AU  - Chocholová, Eva - Drozdová, Eva - Fialová, Dana - Roudnický, Pavel - Zdráhal, Zbyněk - Zwinsová, Barbora - Novotná, Kateřina - Pardy, Filip - Hynšt, Jakub - Peška, Marek - Zůbek, Antonín - Mrázová, Kateřina - Krzyžánek, Vladislav - Doubek, Michael - Pospíšilová, Šárka
PY  - 2022
TI  - Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
JF  - Folia Mendeliana : supplementum ad Acta Musei Moraviae
VL  - 58
IS  - 1
SP  - 57-61
EP  - 57-61
PB  - Moravian Museum Brno
SN  - 00850748
KW  - Gregor Johann Mendel
KW  - oral microbiome
KW  - dental calculus
KW  - palaeoproteomics
KW  - palaeogenomics
KW  - periodontitis
UR  - http://www.mzm.cz/e-shop?ai%5Baction%5D=list&ai%5Bcontroller%5D=Catalog&ai%5Bf_catid%5D=23&ai%5Bf_name%5D=Folia-Mendeliana
N2  - As part of the interdisciplinary research of abbot and founder of genetics, Gregor Johann Mendel, his dental calculus was sampled to gain insight into his health that could not be obtained by mere genome sequencing. A total of 469 proteins were found after filtering, including proteins related to immunity and oral health. Multiple oral species connected to dental pathology such as periodontitis were confirmed based on both DNA and proteins, originating from Porphyromonas gingivalis, Tannerella forsythia, or Treponema denticola. High abundance of Clostridiales DNA was confirmed, in agreement with mummification by saponification.
ER  -

CHOCHOLOVÁ, Eva, Eva DROZDOVÁ, Dana FIALOVÁ, Pavel ROUDNICKÝ, Zbyněk ZDRÁHAL, Barbora ZWINSOVÁ, Kateřina NOVOTNÁ, Filip PARDY, Jakub HYNŠT, Marek PEŠKA, Antonín ZŮBEK, Kateřina MRÁZOVÁ, Vladislav KRZYŽÁNEK, Michael DOUBEK and Šárka POSPÍŠILOVÁ. Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel. \textit{Folia Mendeliana : supplementum ad Acta Musei Moraviae}. Moravian Museum Brno, 2022, vol.~58, No~1, p.~57-61. ISSN~0085-0748.

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