J 2023

Brain Tissue Oxygen Levels as a Perspective Therapeutic Target in Traumatic Brain Injury. Retrospective Cohort Study

GÁL, Roman, Ondřej HRDÝ, Kamil VRBICA, Jan HUDEC, Andrej MRLIAN et. al.

Basic information

Original name

Brain Tissue Oxygen Levels as a Perspective Therapeutic Target in Traumatic Brain Injury. Retrospective Cohort Study

Authors

GÁL, Roman (203 Czech Republic, belonging to the institution), Ondřej HRDÝ (203 Czech Republic, guarantor, belonging to the institution), Kamil VRBICA (203 Czech Republic, belonging to the institution), Jan HUDEC (203 Czech Republic, belonging to the institution), Andrej MRLIAN (703 Slovakia, belonging to the institution) and Martin SMRČKA (203 Czech Republic, belonging to the institution)

Edition

The Journal of Critical Care Medicine, MAZOVIA, SCIENDO, 2023, 2393-1809

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30221 Critical care medicine and Emergency medicine

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.100 in 2022

RIV identification code

RIV/00216224:14110/23:00130280

Organization unit

Faculty of Medicine

DOI

UT WoS

000930691100003

Keywords in English

critical care; traumatic brain injury; Glasgow Outcome Scale; brain tissue oxygen

Tags

Tags

International impact, Reviewed
Změněno: 5/4/2024 07:44, Mgr. Tereza Miškechová

Abstract

V originále

Introduction: Management of traumatic brain injury (TBI) requires a multidisciplinary approach and represents a significant challenge for both neurosurgeons and intensivists. The role of brain tissue oxygenation (PbtO2) monitoring and its impact on posttraumatic outcomes remains a controversial topic. Aim of the study: Our study aimed to evaluate the impact of PbtO2 monitoring on mortality, 30 days and 6 months neurological outcomes in patients with severe TBI compared with those resulting from standard intracranial pressure (ICP) monitoring. Material and methods: In this retrospective cohort study, we analysed the outcomes of 77 patients with severe TBI who met the inclusion criteria. These patients were divided into two groups, including 37 patients who were managed with ICP and PbtO2 monitoring protocols and 40 patients who were managed using ICP protocols alone. Results: There were no significant differences in demographic data between the two groups. We found no statistically significant differences in mortality or Glasgow Outcome Scale (GOS) scores one month after TBI. However, our results revealed that GOS scores at 6 months had improved significantly among patients managed with PbtO2; this finding was particularly notable for Glasgow Outcome Scale (GOS) scores of 4–5. Close monitoring and management of reductions in PbtO2, particularly by increasing the fraction of inspired oxygen, was associated with higher partial pressures of oxygen in this group. Conclusions: Monitoring of PbtO2 may facilitate the appropriate evaluation and treatment of low PbtO2 and represents a promising tool for the management of patients with severe TBI. Additional studies will be needed to confirm these findings.

Links

MUNI/A/1058/2019, interní kód MU
Name: Porovnání viskoelastického měření přístroji ROTEM® Delta a ClotPro® u pacientů s traumatem. Prospektivní observační studie. (Acronym: ROTCLOT)
Investor: Masaryk University, Category A
MUNI/A/1091/2020, interní kód MU
Name: Kontinuální vs. intermitentní způsob podávání enterální výživy u kriticky nemocných dospělých pacientů, efekt na rychlost dosažení energetického a proteinového cíle, toleranci a výskyt komplikací: randomizovaná prospektivní studie. (Acronym: COINN)
Investor: Masaryk University