There has been established numerous biophysical core facilities and other laboratories enabling users of various backgrounds to use advanced instrumentation. In 2014, the ARBRE-MOBIEU network was initiated, aiming to seed a large-scale pan-European interdisciplinary clustering, allowing to ally and synergize the power of spectroscopic, hydrodynamic, real-time microfluidic, thermodynamic, and single-molecule approaches. In 2021, based on the established contacts and collaborations, the initiative has been turned into a scientific society ARBRE (Association of Resources for Biophysical Research in Europe).