Telomerase RNA in Hymenoptera (Insecta) switched to
plant/ciliate-like biogenesis

J 2023

Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis

FAJKUS, Petr, Matej ADÁMIK, Andrew D L NELSON, Agata Magdalena KILAR, Michal FRANEK et. al.

Basic information

Original name

Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis

Authors

FAJKUS, Petr (203 Czech Republic, belonging to the institution), Matej ADÁMIK (703 Slovakia), Andrew D L NELSON, Agata Magdalena KILAR (616 Poland, belonging to the institution), Michal FRANEK (703 Slovakia, belonging to the institution), Michal BUBENÍK (203 Czech Republic, belonging to the institution), Radmila Capkova FRYDRYCHOVA, Alena VOTAVOVA, Eva SÝKOROVÁ (203 Czech Republic), Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution) and Vratislav PEŠKA (203 Czech Republic)

Edition

Nucleic acids research, Oxford, Oxford University Press, 2023, 0305-1048

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 14.900 in 2022

RIV identification code

RIV/00216224:14740/23:00130297

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1093/nar/gkac1202

UT WoS

000902076600001

Keywords in English

TEMPLATE-BOUNDARY DEFINITION;PSEUDOKNOT;SEQUENCE;IDENTIFICATION

Abstract

V originále

In contrast to the catalytic subunit of telomerase, its RNA subunit (TR) is highly divergent in size, sequence and biogenesis pathways across eukaryotes. Current views on TR evolution assume a common origin of TRs transcribed with RNA polymerase II in Opisthokonta (the supergroup including Animalia and Fungi) and Trypanosomida on one hand, and TRs transcribed with RNA polymerase III under the control of type 3 promoter, found in TSAR and Archaeplastida supergroups (including e.g. ciliates and Viridiplantae taxa, respectively). Here, we focus on unknown TRs in one of the largest Animalia order - Hymenoptera (Arthropoda) with more than 300 available representative genomes. Using a combination of bioinformatic and experimental approaches, we identify their TRs. In contrast to the presumed type of TRs (H/ACA box snoRNAs transcribed with RNA Polymerase II) corresponding to their phylogenetic position, we find here short TRs of the snRNA type, likely transcribed with RNA polymerase III under the control of the type 3 promoter. The newly described insect TRs thus question the hitherto assumed monophyletic origin of TRs across Animalia and point to an evolutionary switch in TR type and biogenesis that was associated with the divergence of Arthropods.

Links

GX20-01331X, research and development project

Name: Biogeneze a evoluce telomerázy u rostlin

Investor: Czech Science Foundation

LM2018131, research and development project

Name: Česká národní infrastruktura pro biologická data (Acronym: ELIXIR-CZ)

Investor: Ministry of Education, Youth and Sports of the CR, Czech National Infrastructure for Biological Data

LM2018132, research and development project

Name: Národní centrum lékařské genomiky (Acronym: NCLG)

Investor: Ministry of Education, Youth and Sports of the CR, National Center for Medical Genomics

LM2018140, research and development project

Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

FAJKUS, Petr, Matej ADÁMIK, Andrew D L NELSON, Agata Magdalena KILAR, Michal FRANEK, Michal BUBENÍK, Radmila Capkova FRYDRYCHOVA, Alena VOTAVOVA, Eva SÝKOROVÁ, Jiří FAJKUS and Vratislav PEŠKA. Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis. Nucleic acids research. Oxford: Oxford University Press, 2023, vol. 51, No 1, p. 420-433. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkac1202.

@article{2253648,
   author = {Fajkus, Petr and Adámik, Matej and Nelson, Andrew D L and Kilar, Agata Magdalena and Franek, Michal and Bubeník, Michal and Frydrychova, Radmila Capkova and Votavova, Alena and Sýkorová, Eva and Fajkus, Jiří and Peška, Vratislav},
   article_location = {Oxford},
   article_number = {1},
   doi = {http://dx.doi.org/10.1093/nar/gkac1202},
   keywords = {TEMPLATE-BOUNDARY DEFINITION;PSEUDOKNOT;SEQUENCE;IDENTIFICATION},
   language = {eng},
   issn = {0305-1048},
   journal = {Nucleic acids research},
   title = {Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis},
   url = {https://academic.oup.com/nar/article/51/1/420/6956357},
   volume = {51},
   year = {2023}
}

TY  - JOUR
ID  - 2253648
AU  - Fajkus, Petr - Adámik, Matej - Nelson, Andrew D L - Kilar, Agata Magdalena - Franek, Michal - Bubeník, Michal - Frydrychova, Radmila Capkova - Votavova, Alena - Sýkorová, Eva - Fajkus, Jiří - Peška, Vratislav
PY  - 2023
TI  - Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis
JF  - Nucleic acids research
VL  - 51
IS  - 1
SP  - 420-433
EP  - 420-433
PB  - Oxford University Press
SN  - 03051048
KW  - TEMPLATE-BOUNDARY DEFINITION;PSEUDOKNOT;SEQUENCE;IDENTIFICATION
UR  - https://academic.oup.com/nar/article/51/1/420/6956357
N2  - In contrast to the catalytic subunit of telomerase, its RNA subunit (TR) is highly divergent in size, sequence and biogenesis pathways across eukaryotes. Current views on TR evolution assume a common origin of TRs transcribed with RNA polymerase II in Opisthokonta (the supergroup including Animalia and Fungi) and Trypanosomida on one hand, and TRs transcribed with RNA polymerase III under the control of type 3 promoter, found in TSAR and Archaeplastida supergroups (including e.g. ciliates and Viridiplantae taxa, respectively). Here, we focus on unknown TRs in one of the largest Animalia order - Hymenoptera (Arthropoda) with more than 300 available representative genomes. Using a combination of bioinformatic and experimental approaches, we identify their TRs. In contrast to the presumed type of TRs (H/ACA box snoRNAs transcribed with RNA Polymerase II) corresponding to their phylogenetic position, we find here short TRs of the snRNA type, likely transcribed with RNA polymerase III under the control of the type 3 promoter. The newly described insect TRs thus question the hitherto assumed monophyletic origin of TRs across Animalia and point to an evolutionary switch in TR type and biogenesis that was associated with the divergence of Arthropods.
ER  -

FAJKUS, Petr, Matej ADÁMIK, Andrew D L NELSON, Agata Magdalena KILAR, Michal FRANEK, Michal BUBENÍK, Radmila Capkova FRYDRYCHOVA, Alena VOTAVOVA, Eva SÝKOROVÁ, Jiří FAJKUS and Vratislav PEŠKA. Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2023, vol.~51, No~1, p.~420-433. ISSN~0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkac1202.

Detailed Information on Publication Record