| FOŘTOVÁ, Andrea, Václav HÖNIG, Jiří SALÁT, Martin PALUS, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Andrey V. BARKHASH, Michal F. KRIHA, Ales CHRDLE, Marie LIPOLDOVA and Daniel RŮŽEK. Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients. Virus Research. Elsevier, 2023, vol. 324, January 2023, p. 1-8. ISSN 0168-1702. Available from: https://dx.doi.org/10.1016/j.virusres.2022.199020. |
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@article{2254098,
author = {Fořtová, Andrea and Hönig, Václav and Salát, Jiří and Palus, Martin and Pýchová, Martina and Krbková, Lenka and Barkhash, Andrey V. and Kriha, Michal F. and Chrdle, Ales and Lipoldova, Marie and Růžek, Daniel},
article_number = {January 2023},
doi = {http://dx.doi.org/10.1016/j.virusres.2022.199020},
keywords = {Tick-borne encephalitis; Neuroinfection; Matrix matalloproteinase; Cerebrospinal fluid},
language = {eng},
issn = {0168-1702},
journal = {Virus Research},
title = {Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients.},
url = {https://doi.org/10.1016/j.virusres.2022.199020},
volume = {324},
year = {2023}
}
TY - JOUR
ID - 2254098
AU - Fořtová, Andrea - Hönig, Václav - Salát, Jiří - Palus, Martin - Pýchová, Martina - Krbková, Lenka - Barkhash, Andrey V. - Kriha, Michal F. - Chrdle, Ales - Lipoldova, Marie - Růžek, Daniel
PY - 2023
TI - Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients.
JF - Virus Research
VL - 324
IS - January 2023
SP - 1-8
EP - 1-8
PB - Elsevier
SN - 01681702
KW - Tick-borne encephalitis
KW - Neuroinfection
KW - Matrix matalloproteinase
KW - Cerebrospinal fluid
UR - https://doi.org/10.1016/j.virusres.2022.199020
N2 - Matrix metalloproteinases (MMPs) play an important role in central nervous system infections. We analysed the levels of 8 different MMPs in the cerebrospinal fluid (CSF) of 89 adult patients infected with tick-borne encephalitis (TBE) virus and compared them with the levels in a control group. MMP-9 was the only MMP that showed significantly increased CSF levels in TBE patients. Serum MMP-9 levels were subsequently measured in 101 adult TBE patients at various time points during the neurological phase of TBE and at follow-up. In addition, serum MMP-9 was analysed in 37 paediatric TBE patients. Compared with control levels, both paediatric and adult TBE patients had significantly elevated serum MMP-9 levels. In most adult patients, serum MMP-9 levels peaked at hospital admission, with higher serum MMP-9 levels observed in patients with encephalitis than in patients with meningitis. Elevated serum MMP-9 levels were observed throughout hospitalisation but decreased to normal levels at follow-up. Serum MMP-9 levels correlated with clinical course, especially in patients heterozygous for the single-nucleotide polymorphism rs17576 (A/G; Gln279Arg) in the MMP9 gene. The results highlight the importance of MMP-9 in the pathogenesis of TBE and suggest that serum MMP-9 may serve as a promising bioindicator of TBE in both paediatric and adult TBE patients.
ER -
FOŘTOVÁ, Andrea, Václav HÖNIG, Jiří SALÁT, Martin PALUS, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Andrey V. BARKHASH, Michal F. KRIHA, Ales CHRDLE, Marie LIPOLDOVA and Daniel RŮŽEK. Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients. \textit{Virus Research}. Elsevier, 2023, vol.~324, January 2023, p.~1-8. ISSN~0168-1702. Available from: https://dx.doi.org/10.1016/j.virusres.2022.199020.
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