New directions in the experimental therapy of tick-borne
encephalitis.

J 2023

New directions in the experimental therapy of tick-borne encephalitis.

EYER, Luděk, Katherine SELEY-RADTKE and Daniel RŮŽEK

Basic information

Original name

New directions in the experimental therapy of tick-borne encephalitis.

Authors

EYER, Luděk (203 Czech Republic, belonging to the institution), Katherine SELEY-RADTKE and Daniel RŮŽEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Antiviral Research, Elsevier B.V. 2023, 0166-3542

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10607 Virology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.600 in 2022

RIV identification code

RIV/00216224:14310/23:00130312

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.antiviral.2022.105504

UT WoS

000997347600001

Keywords in English

Tick-borne encephalitis; Tick-borne encephalitis virus; Antivirals; Monoclonal antibodies; Immunotherapy

Abstract

V originále

Tick-borne encephalitis (TBE) is a potentially fatal disease common in much of Europe and Asia. There is no specific therapy for the treatment of TBE patients. However, several efforts are being made to develop small molecules that specifically interfere with the life cycle of TBE virus. In particular, recently various nucleoside analogues that can inhibit the viral replicase, such as the RNA-dependent RNA polymerase or viral methyltransferases, have been explored. In addition, human or chimeric (i.e., structural chimeras that combine mouse variable domains with human constant domains) monoclonal antibodies with promising potential for post-exposure prophylaxis or early therapy have been developed. This review summarizes the latest directions and experimental approaches that may be used to combat TBE in humans.

Citovat

EYER, Luděk, Katherine SELEY-RADTKE and Daniel RŮŽEK. New directions in the experimental therapy of tick-borne encephalitis. Antiviral Research. Elsevier B.V., 2023, vol. 210, February, p. 1-6. ISSN 0166-3542. Available from: https://dx.doi.org/10.1016/j.antiviral.2022.105504.

@article{2254099,
   author = {Eyer, Luděk and SeleyandRadtke, Katherine and Růžek, Daniel},
   article_number = {February},
   doi = {http://dx.doi.org/10.1016/j.antiviral.2022.105504},
   keywords = {Tick-borne encephalitis; Tick-borne encephalitis virus; Antivirals; Monoclonal antibodies; Immunotherapy},
   language = {eng},
   issn = {0166-3542},
   journal = {Antiviral Research},
   title = {New directions in the experimental therapy of tick-borne encephalitis.},
   url = {https://doi.org/10.1016/j.antiviral.2022.105504},
   volume = {210},
   year = {2023}
}

TY  - JOUR
ID  - 2254099
AU  - Eyer, Luděk - Seley-Radtke, Katherine - Růžek, Daniel
PY  - 2023
TI  - New directions in the experimental therapy of tick-borne encephalitis.
JF  - Antiviral Research
VL  - 210
IS  - February
SP  - 1-6
EP  - 1-6
PB  - Elsevier B.V.
SN  - 01663542
KW  - Tick-borne encephalitis
KW  - Tick-borne encephalitis virus
KW  - Antivirals
KW  - Monoclonal antibodies
KW  - Immunotherapy
UR  - https://doi.org/10.1016/j.antiviral.2022.105504
N2  - Tick-borne encephalitis (TBE) is a potentially fatal disease common in much of Europe and Asia. There is no specific therapy for the treatment of TBE patients. However, several efforts are being made to develop small molecules that specifically interfere with the life cycle of TBE virus. In particular, recently various nucleoside analogues that can inhibit the viral replicase, such as the RNA-dependent RNA polymerase or viral methyltransferases, have been explored. In addition, human or chimeric (i.e., structural chimeras that combine mouse variable domains with human constant domains) monoclonal antibodies with promising potential for post-exposure prophylaxis or early therapy have been developed. This review summarizes the latest directions and experimental approaches that may be used to combat TBE in humans.
ER  -

EYER, Luděk, Katherine SELEY-RADTKE and Daniel RŮŽEK. New directions in the experimental therapy of tick-borne encephalitis. \textit{Antiviral Research}. Elsevier B.V., 2023, vol.~210, February, p.~1-6. ISSN~0166-3542. Available from: https://dx.doi.org/10.1016/j.antiviral.2022.105504.

Detailed Information on Publication Record