Detailed Information on Publication Record
2023
Causes of Intensive Care Unit Admissions in Children with SARS-CoV-2: Single-Centre Observational Study
HOMOLA, Lukáš, Jozef KLUČKA, Dominik FABIÁN, Petr ŠTOURAČ, Josef ŠIKULA et. al.Basic information
Original name
Causes of Intensive Care Unit Admissions in Children with SARS-CoV-2: Single-Centre Observational Study
Authors
HOMOLA, Lukáš (203 Czech Republic, belonging to the institution), Jozef KLUČKA (703 Slovakia, belonging to the institution), Dominik FABIÁN (203 Czech Republic, belonging to the institution), Petr ŠTOURAČ (203 Czech Republic, belonging to the institution), Josef ŠIKULA (203 Czech Republic), Eva VÁVROVÁ (203 Czech Republic), Barbora JEŘÁBKOVÁ (203 Czech Republic), Martin SIHLOVEC (703 Slovakia), Václav MUSIL (203 Czech Republic, belonging to the institution), Klára ŠPANĚLOVÁ (203 Czech Republic), Patrícia MUŽLAYOVÁ (703 Slovakia, belonging to the institution) and Pavlína DANHOFER (203 Czech Republic, guarantor, belonging to the institution)
Edition
Children, Basel, MDPI, 2023, 2227-9067
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30221 Critical care medicine and Emergency medicine
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.400 in 2022
RIV identification code
RIV/00216224:14110/23:00130328
Organization unit
Faculty of Medicine
UT WoS
000917039700001
Keywords in English
COVID-19; SARS-CoV-2; children; intensive care; ICU; MIS-C; isolation
Tags
International impact, Reviewed
Změněno: 11/7/2023 11:06, Mgr. Tereza Miškechová
Abstract
V originále
Background: The proportion of intensive care unit (ICU) admissions in children that have and have not been directly caused by SARS-CoV-2 remains unclear. The aim of the study is to analyse a cohort of children admitted to the ICU with SARS-CoV-2 and determine whether the infection was the primary cause of their hospitalisation, a significant contributor, a suspected accomplice, or an incidental finding. Methods: This was a retrospective observational study of all the children admitted to the ICU with SARS-CoV-2 from March 2020 to February 2022 from the South Moravia region. The aim of the study was to assess whether the hospitalisation was likely to be directly caused by the virus (i.e., patients with acute COVID-19; the COVID group), whether the virus was a significant contributor to the hospitalisation (i.e., patients with multisystem inflammatory syndrome in children due to COVID-19; the MIS-C group), whether it may have contributed to the worsening of their underlying disease (the WORSENING group), or whether it was an incidental finding very likely unrelated to hospitalisation where SARS-CoV-2 positivity merely placed patients in the COVID-19 unit (the ISOLATION group). The groups were compared using a series of secondary outcomes. Results: The study population represented 150 paediatric ICU cases (age 8.6; IQR 3.5–13.3 years), with 66.7% being male. The COVID group represented 32.7% of cases (49/150); MIS-C, 30% (45/150); WORSENING, 14.7% (22/150); and ISOLATION, 22.7% (34/150). The median length of hospitalisation was found for the MIS-C group (11 days; 9 days in the ICU), the COVID group (6 days; five days in the ICU), WORSENING group (4.5 days; 4.5 days in the ICU) and the ISOLATION group (5.5 days; 3.5 days in the ICU), where the difference was significant (p < 0.001). Asymptomatic and mild cases were most common in the WORSENING (36.4% and 63.6%) and ISOLATION (52.9% and 44.1%) groups. Severe and critical cases were only present in the COVID (6.1% and 12.2%) and MIS-C (4.4% and 11.1%) groups; the severity difference was significant (p < 0.001). The groups did not differ significantly in the proportion of complete recovery and short- and long-term sequelae (p = 0.09).
Links
| MUNI/A/1404/2021, interní kód MU |
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