Detailed Information on Publication Record
2022
ヌクレアーゼの阻害剤としての置換アミノチアゾール
PARUCH, Kamil, Benoit Jean-Pierre CARBAIN, Štěpán HAVEL, Jiří DAMBORSKÝ, Jan BREZOVSKÝ et. al.Basic information
Original name
ヌクレアーゼの阻害剤としての置換アミノチアゾール
Name (in English)
Substituted aminothiazoles as inhibitors of nucleases
Authors
PARUCH, Kamil (203 Czech Republic, belonging to the institution), Benoit Jean-Pierre CARBAIN (250 France, belonging to the institution), Štěpán HAVEL (203 Czech Republic, belonging to the institution), Jiří DAMBORSKÝ (203 Czech Republic, belonging to the institution), Jan BREZOVSKÝ (203 Czech Republic, belonging to the institution), Lukáš DANIEL (203 Czech Republic, belonging to the institution), Alexandra SISÁKOVÁ (703 Slovakia, belonging to the institution), Fedor NIKULENKOV (203 Czech Republic, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, belonging to the institution)
Edition
Number: JP7175031, Publisher: Japan Patent Office (JPO), Place of publication: Kasumigaseki Chiyoda-ku, Tokyo, Owner's name: Masarykova univerzita, 2022
Other information
Language
Japanese
Type of outcome
Patent
Field of Study
10401 Organic chemistry
Country of publisher
Japan
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14310/22:00128639
Organization unit
Faculty of Science
Keywords in English
DNA; propanamide; nuclease
Tags
International impact
Změněno: 14/2/2023 17:38, Mgr. Marie Šípková, DiS.
V originále
本発明は、構造式（１）で表される化合物を提供する：【化１】 式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６は、請求項で定義されている通りである。当該化合物はヌクレアーゼの阻害剤であり、特に、増殖性疾患、神経変性疾患、および他のゲノム不安定性関連疾患の治療および／または予防の方法において有用である。
In English
Compounds represented by the structural formula (1) where R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
Links
| EF16_025/0007381, research and development project |
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| LM2018130, research and development project |
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