Comparative Study of Powder Carriers Physical and Structural
Properties

J 2022

Comparative Study of Powder Carriers Physical and Structural Properties

KOSTELANSKÁ, Klára, Barbora Blahova PRUDILOVA, Sylva HOLESOVA, Jakub VLCEK, David VETCHÝ et. al.

Basic information

Original name

Comparative Study of Powder Carriers Physical and Structural Properties

Authors

KOSTELANSKÁ, Klára (203 Czech Republic, belonging to the institution), Barbora Blahova PRUDILOVA, Sylva HOLESOVA, Jakub VLCEK, David VETCHÝ (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Pharmaceutics, Basel, MDPI, 2022, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.400

RIV identification code

RIV/00216224:14160/22:00128706

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/pharmaceutics14040818

UT WoS

000785406900001

Keywords in English

powder carriers; adsorption; aluminometasilicates; liquisolid systems; solid dosage form; pharmaceutical technology

Abstract

V originále

High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems (s-SEDDS). Besides widely used microcrystalline cellulose, other promising materials include magnesium aluminometasilicates, mesoporous silicates, and silica aerogels. Clay minerals with laminar or fibrous internal structures also provide suitable properties for liquid drug incorporation. This work aimed at a comparison of 14 carriers' main properties. Cellulose derivatives, silica, silicates, and clay minerals were evaluated for flow properties, shear cell experiments, SSA, hygroscopicity, pH, particle size, and SEM. The most promising materials were magnesium aluminometasilicates, specifically Neusilin (R) US2, due to its proper flow, large SSA, etc. Innovative materials such as FujiSil (R) or Syloid (R) XDP 3050 were for their properties evaluated as suitable. The obtained data can help choose a suitable carrier for formulations where the liquid phase is incorporated into the solid dosage form. All measurements were conducted by the same methodology and under the same conditions, allowing a seamless comparison of property evaluation between carriers, for which available company or scientific sources do not qualify due to different measurements, conditions, instrumentation, etc.

Citovat

KOSTELANSKÁ, Klára, Barbora Blahova PRUDILOVA, Sylva HOLESOVA, Jakub VLCEK, David VETCHÝ and Jan GAJDZIOK. Comparative Study of Powder Carriers Physical and Structural Properties. Pharmaceutics. Basel: MDPI, 2022, vol. 14, No 4, p. 1-18. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics14040818.

@article{2259460,
   author = {Kostelanská, Klára and Prudilova, Barbora Blahova and Holesova, Sylva and Vlcek, Jakub and Vetchý, David and Gajdziok, Jan},
   article_location = {Basel},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/pharmaceutics14040818},
   keywords = {powder carriers; adsorption; aluminometasilicates; liquisolid systems; solid dosage form; pharmaceutical technology},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Comparative Study of Powder Carriers Physical and Structural Properties},
   url = {https://www.mdpi.com/1999-4923/14/4/818},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 2259460
AU  - Kostelanská, Klára - Prudilova, Barbora Blahova - Holesova, Sylva - Vlcek, Jakub - Vetchý, David - Gajdziok, Jan
PY  - 2022
TI  - Comparative Study of Powder Carriers Physical and Structural Properties
JF  - Pharmaceutics
VL  - 14
IS  - 4
SP  - 1-18
EP  - 1-18
PB  - MDPI
SN  - 19994923
KW  - powder carriers
KW  - adsorption
KW  - aluminometasilicates
KW  - liquisolid systems
KW  - solid dosage form
KW  - pharmaceutical technology
UR  - https://www.mdpi.com/1999-4923/14/4/818
N2  - High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems (s-SEDDS). Besides widely used microcrystalline cellulose, other promising materials include magnesium aluminometasilicates, mesoporous silicates, and silica aerogels. Clay minerals with laminar or fibrous internal structures also provide suitable properties for liquid drug incorporation. This work aimed at a comparison of 14 carriers' main properties. Cellulose derivatives, silica, silicates, and clay minerals were evaluated for flow properties, shear cell experiments, SSA, hygroscopicity, pH, particle size, and SEM. The most promising materials were magnesium aluminometasilicates, specifically Neusilin (R) US2, due to its proper flow, large SSA, etc. Innovative materials such as FujiSil (R) or Syloid (R) XDP 3050 were for their properties evaluated as suitable. The obtained data can help choose a suitable carrier for formulations where the liquid phase is incorporated into the solid dosage form. All measurements were conducted by the same methodology and under the same conditions, allowing a seamless comparison of property evaluation between carriers, for which available company or scientific sources do not qualify due to different measurements, conditions, instrumentation, etc.
ER  -

KOSTELANSKÁ, Klára, Barbora Blahova PRUDILOVA, Sylva HOLESOVA, Jakub VLCEK, David VETCHÝ and Jan GAJDZIOK. Comparative Study of Powder Carriers Physical and Structural Properties. \textit{Pharmaceutics}. Basel: MDPI, 2022, vol.~14, No~4, p.~1-18. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics14040818.

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