Metals and Trace Elements in Calcified Valves in Patiens with
Acquired Severe Aortic Valve Stenosisi: Is There a Connction
with the Degeneration Process ?

J 2023

Metals and Trace Elements in Calcified Valves in Patiens with Acquired Severe Aortic Valve Stenosisi: Is There a Connction with the Degeneration Process ?

TOMÁŠEK, Aleš, Jan MAŇOUŠEK, Jan KUTA, Jiří HLÁSENSKÝ, Leoš KŘEN et. al.

Basic information

Original name

Metals and Trace Elements in Calcified Valves in Patiens with Acquired Severe Aortic Valve Stenosisi: Is There a Connction with the Degeneration Process ?

Name in Czech

Kovy a stopové prvky ve zvápenatělých chlopních u pacientů se získanou těžkou stenózou aortální chlopně: Existuje souvislost s procesem degenerace?

Authors

TOMÁŠEK, Aleš (203 Czech Republic), Jan MAŇOUŠEK (203 Czech Republic, belonging to the institution), Jan KUTA (203 Czech Republic, belonging to the institution), Jiří HLÁSENSKÝ (203 Czech Republic, guarantor, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Martin ŠINDLER (703 Slovakia, belonging to the institution), Michal ZELENÝ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution) and Petr NĚMEC (203 Czech Republic)

Edition

JOURNAL OF PERSONALIZED MEDICINE, BASEL, MDPI, 2023, 2075-4426

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.508 in 2021

RIV identification code

RIV/00216224:14110/23:00130372

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/jpm13020320

UT WoS

000941325100001

Keywords in English

aortic valve stenosis; calcification; metals and trace elements; biomonitoring; biological effects

Abstract

V originále

first_pagesettingsOrder Article Reprints Open AccessArticle Metals and Trace Elements in Calcified Valves in Patients with Acquired Severe Aortic Valve Stenosis: Is There a Connection with the Degeneration Process? by Aleš Tomášek 1,Jan Maňoušek 2ORCID,Jan Kuta 3,Jiří Hlásenský 2,*,Leoš Křen 4,Martin Šindler 5,Michal Zelený 5,Petr Kala 2 andPetr Němec 1 1 Centre for Cardiovascular Surgery and Transplantation, Pekařská 53, 656 91 Brno, Czech Republic 2 Department of Internal Cardiology Medicine, University Hospital and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00 Brno, Czech Republic 3 Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic 4 Institute of Pathology, University Hospital and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00 Brno, Czech Republic 5 Institute of Forensic Medicine, St Anne’s University Hospital and Faculty of Medicine, Masaryk University, Tvrdého 2a, 662 99 Brno, Czech Republic * Author to whom correspondence should be addressed. J. Pers. Med. 2023, 13(2), 320; https://doi.org/10.3390/jpm13020320 Received: 4 December 2022 / Revised: 30 January 2023 / Accepted: 7 February 2023 / Published: 13 February 2023 Download Review Reports Versions Notes Abstract Background. Acquired calcified aortic valve stenosis is the most common valve disease in adulthood. In the etiopathogenesis of this complex pathology, the importance of inflammation is mentioned, in which non-infectious influences represented by the biological effects of metal pollutants may participate. The main goal of the study was to determine the concentration of 21 metals and trace elements—aluminium (Al), barium (Ba), cadmium (Cd), calcium (Ca), chrome (Cr), cobalt (Co), copper (Cu), gold (Au), lead (Pb), magnesium (Mg), mercury (Hg), molybdenum (Mo), nickel (Ni), phosphorus (P), selenium (Se), strontium (Sr), sulfur (S), tin (Sn), titanium (Ti), vanadium (V) and zinc (Zn)—in the tissue of calcified aortic valves and to compare them with the concentrations of the same elements in the tissue of healthy aortic valves in the control group. Material and methods. The study group consisted of 49 patients (25 men, mean age: 74) with acquired, severe, calcified aortic valve stenosis with indicated heart surgery. The control group included 34 deceased (20 men, median age: 53) with no evidence of heart disease. Calcified valves were explanted during cardiac surgery and deep frozen. Similarly, the valves of the control group were removed. All valves were lyophilized and analyzed by inductively coupled plasma mass spectrometry. The concentrations of selected elements were compared by means of standard statistical methods. Results. Calcified aortic valves contained significantly higher (p < 0.05) concentrations of Ba, Ca, Co, Cr, Mg, P, Pb, Se, Sn, Sr and Zn and—in contrast—lower concentrations of Cd, Cu, Mo, S and V than valves of the control group. Significant positive correlations of concentrations between the pairs Ca-P, Cu-S and Se-S and strong negative correlations between the elements Mg-Se, P-S and Ca-S were found in the affected valves. Conclusion. Aortic valve calcification is associated with increased tissue accumulation of the majority of the analyzed elements, including metal pollutants. Some exposure factors may increase their accumulation in the valve tissue. A relationship between exposure to environmental burden and the aortic valve calcification process cannot be ruled out. Advances in histochemical and imaging techniques allowing imaging of metal pollutants directly in valve tissue may represent an important future perspective.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

90121, large research infrastructures

Name: RECETOX RI

Citovat

TOMÁŠEK, Aleš, Jan MAŇOUŠEK, Jan KUTA, Jiří HLÁSENSKÝ, Leoš KŘEN, Martin ŠINDLER, Michal ZELENÝ, Petr KALA and Petr NĚMEC. Metals and Trace Elements in Calcified Valves in Patiens with Acquired Severe Aortic Valve Stenosisi: Is There a Connction with the Degeneration Process ? JOURNAL OF PERSONALIZED MEDICINE. BASEL: MDPI, 2023, vol. 13, No 2, p. 1-15. ISSN 2075-4426. Available from: https://dx.doi.org/10.3390/jpm13020320.

@article{2261697,
   author = {Tomášek, Aleš and Maňoušek, Jan and Kuta, Jan and Hlásenský, Jiří and Křen, Leoš and Šindler, Martin and Zelený, Michal and Kala, Petr and Němec, Petr},
   article_location = {BASEL},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/jpm13020320},
   keywords = {aortic valve stenosis; calcification; metals and trace elements; biomonitoring; biological effects},
   language = {eng},
   issn = {2075-4426},
   journal = {JOURNAL OF PERSONALIZED MEDICINE},
   title = {Metals and Trace Elements in Calcified Valves in Patiens with Acquired Severe Aortic Valve Stenosisi: Is There a Connction with the Degeneration Process ?},
   url = {https://www.mdpi.com/2075-4426/13/2/320},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2261697
AU  - Tomášek, Aleš - Maňoušek, Jan - Kuta, Jan - Hlásenský, Jiří - Křen, Leoš - Šindler, Martin - Zelený, Michal - Kala, Petr - Němec, Petr
PY  - 2023
TI  - Metals and Trace Elements in Calcified Valves in Patiens with Acquired Severe Aortic Valve Stenosisi: Is There a Connction with the Degeneration Process ?
JF  - JOURNAL OF PERSONALIZED MEDICINE
VL  - 13
IS  - 2
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20754426
KW  - aortic valve stenosis
KW  - calcification
KW  - metals and trace elements
KW  - biomonitoring
KW  - biological effects
UR  - https://www.mdpi.com/2075-4426/13/2/320
N2  - first_pagesettingsOrder Article Reprints Open AccessArticle Metals and Trace Elements in Calcified Valves in Patients with Acquired Severe Aortic Valve Stenosis: Is There a Connection with the Degeneration Process? by Aleš Tomášek 1,Jan Maňoušek 2ORCID,Jan Kuta 3,Jiří Hlásenský 2,*,Leoš Křen 4,Martin Šindler 5,Michal Zelený 5,Petr Kala 2 andPetr Němec 1 1 Centre for Cardiovascular Surgery and Transplantation, Pekařská 53, 656 91 Brno, Czech Republic 2 Department of Internal Cardiology Medicine, University Hospital and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00 Brno, Czech Republic 3 Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic 4 Institute of Pathology, University Hospital and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00 Brno, Czech Republic 5 Institute of Forensic Medicine, St Anne’s University Hospital and Faculty of Medicine, Masaryk University, Tvrdého 2a, 662 99 Brno, Czech Republic * Author to whom correspondence should be addressed. J. Pers. Med. 2023, 13(2), 320; https://doi.org/10.3390/jpm13020320 Received: 4 December 2022 / Revised: 30 January 2023 / Accepted: 7 February 2023 / Published: 13 February 2023 Download Review Reports Versions Notes Abstract Background. Acquired calcified aortic valve stenosis is the most common valve disease in adulthood. In the etiopathogenesis of this complex pathology, the importance of inflammation is mentioned, in which non-infectious influences represented by the biological effects of metal pollutants may participate. The main goal of the study was to determine the concentration of 21 metals and trace elements—aluminium (Al), barium (Ba), cadmium (Cd), calcium (Ca), chrome (Cr), cobalt (Co), copper (Cu), gold (Au), lead (Pb), magnesium (Mg), mercury (Hg), molybdenum (Mo), nickel (Ni), phosphorus (P), selenium (Se), strontium (Sr), sulfur (S), tin (Sn), titanium (Ti), vanadium (V) and zinc (Zn)—in the tissue of calcified aortic valves and to compare them with the concentrations of the same elements in the tissue of healthy aortic valves in the control group. Material and methods. The study group consisted of 49 patients (25 men, mean age: 74) with acquired, severe, calcified aortic valve stenosis with indicated heart surgery. The control group included 34 deceased (20 men, median age: 53) with no evidence of heart disease. Calcified valves were explanted during cardiac surgery and deep frozen. Similarly, the valves of the control group were removed. All valves were lyophilized and analyzed by inductively coupled plasma mass spectrometry. The concentrations of selected elements were compared by means of standard statistical methods. Results. Calcified aortic valves contained significantly higher (p < 0.05) concentrations of Ba, Ca, Co, Cr, Mg, P, Pb, Se, Sn, Sr and Zn and—in contrast—lower concentrations of Cd, Cu, Mo, S and V than valves of the control group. Significant positive correlations of concentrations between the pairs Ca-P, Cu-S and Se-S and strong negative correlations between the elements Mg-Se, P-S and Ca-S were found in the affected valves. Conclusion. Aortic valve calcification is associated with increased tissue accumulation of the majority of the analyzed elements, including metal pollutants. Some exposure factors may increase their accumulation in the valve tissue. A relationship between exposure to environmental burden and the aortic valve calcification process cannot be ruled out. Advances in histochemical and imaging techniques allowing imaging of metal pollutants directly in valve tissue may represent an important future perspective.
ER  -

TOMÁŠEK, Aleš, Jan MAŇOUŠEK, Jan KUTA, Jiří HLÁSENSKÝ, Leoš KŘEN, Martin ŠINDLER, Michal ZELENÝ, Petr KALA and Petr NĚMEC. Metals and Trace Elements in Calcified Valves in Patiens with Acquired Severe Aortic Valve Stenosisi: Is There a Connction with the Degeneration Process ? \textit{JOURNAL OF PERSONALIZED MEDICINE}. BASEL: MDPI, 2023, vol.~13, No~2, p.~1-15. ISSN~2075-4426. Available from: https://dx.doi.org/10.3390/jpm13020320.

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