Acceleration of coronavirus disease (COVID-19) mass vaccination has been a chief priority for health systems globally since the first emergency approvals of COVID-19 vaccines in late 2020. Nevertheless, vaccine hesitancy (VH), which is nourished by misinformation about vaccines' effectiveness and safety, remains as a serious threat for vaccination strategies worldwide. Aversion to post-vaccination side effects, the lack of trust of pharmaceutical industry, and the lack of knowledge about vaccines' safety are among the VH drivers; therefore independent (non-sponsored) and active surveillance of COVID-19 vaccines safety is of utmost importance for suppressing VH.