Pathogenesis of Alzheimer´s disease: Involvement of the choroid
plexus

J 2023

Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus

ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA, Dušan HOLUB, Jan Sebastian NOVOTNY et. al.

Basic information

Original name

Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus

Authors

ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA (703 Slovakia, belonging to the institution), Dušan HOLUB, Jan Sebastian NOVOTNY, Markéta NEZVEDOVÁ (203 Czech Republic, belonging to the institution), Durga JHA (356 India, belonging to the institution), Zuzana NEDELSKA, Valentina LACOVICH, Thijs Vande VYVERE, Ruben HOUBRECHTS, Krystine GARCIA-MANSFIELD, Ritin SHARMA, Victoria DAVID-DIRGO, Martin VYHNALEK, Kateřina TEXLOVA, Hernan CHAVES, Nadine BAKKAR, Lucia PERTIERRA, Mojmír VINKLER (203 Czech Republic, belonging to the institution), Hana MARKOVA, Jan LACZO, Kateřina SHEARDOVÁ (203 Czech Republic, belonging to the institution), Marcela HORTOVA-KOHOUTKOVA, Jan FRIČ, Giancarlo FORTE, Petr KAŇOVSKY, Silvie BELAŠKOVA, Jiří DAMBORSKÝ (203 Czech Republic, belonging to the institution), Jakub HORT, Nicholas T. SEYFRIED, Robert BOWSER, Gustavo SEVLEVER, Robert A. RISSMAN, Richard A. SMITH, Marian HAJDUCH, Patrick PIRROTTE, Zdeněk SPÁČIL (203 Czech Republic, belonging to the institution), Eric B. DAMMER, Clara LIMBÄCK-STOKIN and Gorazd B. STOKIN

Edition

Alzheimer´s & Dementia, Wiley, 2023, 1552-5260

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

DOI

Impact factor

Impact factor: 14.000 in 2022

RIV identification code

RIV/00216224:14310/23:00130379

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/alz.12970

UT WoS

000937916400001

Keywords in English

aging; Alzheimer's disease; cerebrospinal fluid; choroid plexus; pathology

Abstract

V originále

The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

LX22NPO5107, research and development project

Name: Národní ústav pro neurologický výzkum

Investor: Ministry of Education, Youth and Sports of the CR, 5.1 EXCELES

MUNI/G/1131/2017, interní kód MU

Name: Transformative stem cell-based model of Alzheimer’s disease and advanced analytics to study the role of membrane lipids in the pathogenesis

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects

NV19-08-00472, research and development project

Name: Klinicky relevantní biochemické, imunologické a buněčné biomarkery Alzheimerovy nemoci a stárnutí (Acronym: BioMAD)

Investor: Ministry of Health of the CR

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Files attached

2261937.pdf

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Citovat

ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA, Dušan HOLUB, Jan Sebastian NOVOTNY, Markéta NEZVEDOVÁ, Durga JHA, Zuzana NEDELSKA, Valentina LACOVICH, Thijs Vande VYVERE, Ruben HOUBRECHTS, Krystine GARCIA-MANSFIELD, Ritin SHARMA, Victoria DAVID-DIRGO, Martin VYHNALEK, Kateřina TEXLOVA, Hernan CHAVES, Nadine BAKKAR, Lucia PERTIERRA, Mojmír VINKLER, Hana MARKOVA, Jan LACZO, Kateřina SHEARDOVÁ, Marcela HORTOVA-KOHOUTKOVA, Jan FRIČ, Giancarlo FORTE, Petr KAŇOVSKY, Silvie BELAŠKOVA, Jiří DAMBORSKÝ, Jakub HORT, Nicholas T. SEYFRIED, Robert BOWSER, Gustavo SEVLEVER, Robert A. RISSMAN, Richard A. SMITH, Marian HAJDUCH, Patrick PIRROTTE, Zdeněk SPÁČIL, Eric B. DAMMER, Clara LIMBÄCK-STOKIN and Gorazd B. STOKIN. Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus. Alzheimer´s & Dementia. Wiley, 2023, vol. 19, No 8, p. 3537-3554. ISSN 1552-5260. Available from: https://dx.doi.org/10.1002/alz.12970.

@article{2261937,
   author = {Čarna, Maria and Onyango, Isaac G. and Katina, Stanislav and Holub, Dušan and Novotny, Jan Sebastian and Nezvedová, Markéta and Jha, Durga and Nedelska, Zuzana and Lacovich, Valentina and Vyvere, Thijs Vande and Houbrechts, Ruben and GarciaandMansfield, Krystine and Sharma, Ritin and DavidandDirgo, Victoria and Vyhnalek, Martin and Texlova, Kateřina and Chaves, Hernan and Bakkar, Nadine and Pertierra, Lucia and Vinkler, Mojmír and Markova, Hana and Laczo, Jan and Sheardová, Kateřina and HortovaandKohoutkova, Marcela and Frič, Jan and Forte, Giancarlo and Kaňovsky, Petr and Belaškova, Silvie and Damborský, Jiří and Hort, Jakub and Seyfried, Nicholas T. and Bowser, Robert and Sevlever, Gustavo and Rissman, Robert A. and Smith, Richard A. and Hajduch, Marian and Pirrotte, Patrick and Spáčil, Zdeněk and Dammer, Eric B. and LimbäckandStokin, Clara and Stokin, Gorazd B.},
   article_number = {8},
   doi = {http://dx.doi.org/10.1002/alz.12970},
   keywords = {aging; Alzheimer's disease; cerebrospinal fluid; choroid plexus; pathology},
   language = {eng},
   issn = {1552-5260},
   journal = {Alzheimer´s & Dementia},
   title = {Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus},
   url = {https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12970},
   volume = {19},
   year = {2023}
}

TY  - JOUR
ID  - 2261937
AU  - Čarna, Maria - Onyango, Isaac G. - Katina, Stanislav - Holub, Dušan - Novotny, Jan Sebastian - Nezvedová, Markéta - Jha, Durga - Nedelska, Zuzana - Lacovich, Valentina - Vyvere, Thijs Vande - Houbrechts, Ruben - Garcia-Mansfield, Krystine - Sharma, Ritin - David-Dirgo, Victoria - Vyhnalek, Martin - Texlova, Kateřina - Chaves, Hernan - Bakkar, Nadine - Pertierra, Lucia - Vinkler, Mojmír - Markova, Hana - Laczo, Jan - Sheardová, Kateřina - Hortova-Kohoutkova, Marcela - Frič, Jan - Forte, Giancarlo - Kaňovsky, Petr - Belaškova, Silvie - Damborský, Jiří - Hort, Jakub - Seyfried, Nicholas T. - Bowser, Robert - Sevlever, Gustavo - Rissman, Robert A. - Smith, Richard A. - Hajduch, Marian - Pirrotte, Patrick - Spáčil, Zdeněk - Dammer, Eric B. - Limbäck-Stokin, Clara - Stokin, Gorazd B.
PY  - 2023
TI  - Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus
JF  - Alzheimer´s & Dementia
VL  - 19
IS  - 8
SP  - 3537-3554
EP  - 3537-3554
PB  - Wiley
SN  - 15525260
KW  - aging
KW  - Alzheimer's disease
KW  - cerebrospinal fluid
KW  - choroid plexus
KW  - pathology
UR  - https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12970
N2  - The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD.
ER  -

ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA, Dušan HOLUB, Jan Sebastian NOVOTNY, Markéta NEZVEDOVÁ, Durga JHA, Zuzana NEDELSKA, Valentina LACOVICH, Thijs Vande VYVERE, Ruben HOUBRECHTS, Krystine GARCIA-MANSFIELD, Ritin SHARMA, Victoria DAVID-DIRGO, Martin VYHNALEK, Kateřina TEXLOVA, Hernan CHAVES, Nadine BAKKAR, Lucia PERTIERRA, Mojmír VINKLER, Hana MARKOVA, Jan LACZO, Kateřina SHEARDOVÁ, Marcela HORTOVA-KOHOUTKOVA, Jan FRIČ, Giancarlo FORTE, Petr KAŇOVSKY, Silvie BELAŠKOVA, Jiří DAMBORSKÝ, Jakub HORT, Nicholas T. SEYFRIED, Robert BOWSER, Gustavo SEVLEVER, Robert A. RISSMAN, Richard A. SMITH, Marian HAJDUCH, Patrick PIRROTTE, Zdeněk SPÁČIL, Eric B. DAMMER, Clara LIMBÄCK-STOKIN and Gorazd B. STOKIN. Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus. \textit{Alzheimer´s \&{} Dementia}. Wiley, 2023, vol.~19, No~8, p.~3537-3554. ISSN~1552-5260. Available from: https://dx.doi.org/10.1002/alz.12970.

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