| ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA, Dušan HOLUB, Jan Sebastian NOVOTNY, Markéta NEZVEDOVÁ, Durga JHA, Zuzana NEDELSKA, Valentina LACOVICH, Thijs Vande VYVERE, Ruben HOUBRECHTS, Krystine GARCIA-MANSFIELD, Ritin SHARMA, Victoria DAVID-DIRGO, Martin VYHNALEK, Kateřina TEXLOVA, Hernan CHAVES, Nadine BAKKAR, Lucia PERTIERRA, Mojmír VINKLER, Hana MARKOVA, Jan LACZO, Kateřina SHEARDOVÁ, Marcela HORTOVA-KOHOUTKOVA, Jan FRIČ, Giancarlo FORTE, Petr KAŇOVSKY, Silvie BELAŠKOVA, Jiří DAMBORSKÝ, Jakub HORT, Nicholas T. SEYFRIED, Robert BOWSER, Gustavo SEVLEVER, Robert A. RISSMAN, Richard A. SMITH, Marian HAJDUCH, Patrick PIRROTTE, Zdeněk SPÁČIL, Eric B. DAMMER, Clara LIMBÄCK-STOKIN a Gorazd B. STOKIN. Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus. Alzheimer´s & Dementia. Wiley, 2023, roč. 19, č. 8, s. 3537-3554. ISSN 1552-5260. Dostupné z: https://dx.doi.org/10.1002/alz.12970. |
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@article{2261937,
author = {Čarna, Maria and Onyango, Isaac G. and Katina, Stanislav and Holub, Dušan and Novotny, Jan Sebastian and Nezvedová, Markéta and Jha, Durga and Nedelska, Zuzana and Lacovich, Valentina and Vyvere, Thijs Vande and Houbrechts, Ruben and GarciaandMansfield, Krystine and Sharma, Ritin and DavidandDirgo, Victoria and Vyhnalek, Martin and Texlova, Kateřina and Chaves, Hernan and Bakkar, Nadine and Pertierra, Lucia and Vinkler, Mojmír and Markova, Hana and Laczo, Jan and Sheardová, Kateřina and HortovaandKohoutkova, Marcela and Frič, Jan and Forte, Giancarlo and Kaňovsky, Petr and Belaškova, Silvie and Damborský, Jiří and Hort, Jakub and Seyfried, Nicholas T. and Bowser, Robert and Sevlever, Gustavo and Rissman, Robert A. and Smith, Richard A. and Hajduch, Marian and Pirrotte, Patrick and Spáčil, Zdeněk and Dammer, Eric B. and LimbäckandStokin, Clara and Stokin, Gorazd B.},
article_number = {8},
doi = {http://dx.doi.org/10.1002/alz.12970},
keywords = {aging; Alzheimer's disease; cerebrospinal fluid; choroid plexus; pathology},
language = {eng},
issn = {1552-5260},
journal = {Alzheimer´s & Dementia},
title = {Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus},
url = {https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12970},
volume = {19},
year = {2023}
}
TY - JOUR
ID - 2261937
AU - Čarna, Maria - Onyango, Isaac G. - Katina, Stanislav - Holub, Dušan - Novotny, Jan Sebastian - Nezvedová, Markéta - Jha, Durga - Nedelska, Zuzana - Lacovich, Valentina - Vyvere, Thijs Vande - Houbrechts, Ruben - Garcia-Mansfield, Krystine - Sharma, Ritin - David-Dirgo, Victoria - Vyhnalek, Martin - Texlova, Kateřina - Chaves, Hernan - Bakkar, Nadine - Pertierra, Lucia - Vinkler, Mojmír - Markova, Hana - Laczo, Jan - Sheardová, Kateřina - Hortova-Kohoutkova, Marcela - Frič, Jan - Forte, Giancarlo - Kaňovsky, Petr - Belaškova, Silvie - Damborský, Jiří - Hort, Jakub - Seyfried, Nicholas T. - Bowser, Robert - Sevlever, Gustavo - Rissman, Robert A. - Smith, Richard A. - Hajduch, Marian - Pirrotte, Patrick - Spáčil, Zdeněk - Dammer, Eric B. - Limbäck-Stokin, Clara - Stokin, Gorazd B.
PY - 2023
TI - Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus
JF - Alzheimer´s & Dementia
VL - 19
IS - 8
SP - 3537-3554
EP - 3537-3554
PB - Wiley
SN - 15525260
KW - aging
KW - Alzheimer's disease
KW - cerebrospinal fluid
KW - choroid plexus
KW - pathology
UR - https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12970
N2 - The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD.
ER -
ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA, Dušan HOLUB, Jan Sebastian NOVOTNY, Markéta NEZVEDOVÁ, Durga JHA, Zuzana NEDELSKA, Valentina LACOVICH, Thijs Vande VYVERE, Ruben HOUBRECHTS, Krystine GARCIA-MANSFIELD, Ritin SHARMA, Victoria DAVID-DIRGO, Martin VYHNALEK, Kateřina TEXLOVA, Hernan CHAVES, Nadine BAKKAR, Lucia PERTIERRA, Mojmír VINKLER, Hana MARKOVA, Jan LACZO, Kateřina SHEARDOVÁ, Marcela HORTOVA-KOHOUTKOVA, Jan FRIČ, Giancarlo FORTE, Petr KAŇOVSKY, Silvie BELAŠKOVA, Jiří DAMBORSKÝ, Jakub HORT, Nicholas T. SEYFRIED, Robert BOWSER, Gustavo SEVLEVER, Robert A. RISSMAN, Richard A. SMITH, Marian HAJDUCH, Patrick PIRROTTE, Zdeněk SPÁČIL, Eric B. DAMMER, Clara LIMBÄCK-STOKIN a Gorazd B. STOKIN. Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus. \textit{Alzheimer´s \&{} Dementia}. Wiley, 2023, roč.~19, č.~8, s.~3537-3554. ISSN~1552-5260. Dostupné z: https://dx.doi.org/10.1002/alz.12970.
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