A haemochromatosis-causing HFE mutation is associated with
SARS-CoV-2 susceptibility in the Czech population

J 2023

A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK, Ladislav DUŠEK et. al.

Basic information

Original name

A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

Authors

HUBACEK, J. A. (203 Czech Republic, guarantor), T. PHILIPP (203 Czech Republic), V. ADAMKOVA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)

Edition

Clinica Chimica Acta, AMSTERDAM, ELSEVIER SCIENCE BV, 2023, 0009-8981

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30230 Other clinical medicine subjects

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.000 in 2022

RIV identification code

RIV/00216224:14110/23:00130381

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.cca.2022.12.025

UT WoS

000923428500001

Keywords in English

COVID-19; HFE; Iron; Polymorphism; Susceptibility

Abstract

V originále

Background: Coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, has become a global pandemic. While susceptibility to COVID-19 is subject to several external factors, including hypertension, BMI, and the presence of diabetes, it is also genetically determined to a significant extent. Infectious agents require iron (Fe) for proper functioning. Carriers of mutations resulting in increased iron concentrations are understood to be at increased risk of COVID-19.Methods: We examined HFE genotypes associated with hereditary haemochromatosis (rs1800562 and rs1799945 SNPs) in 617 COVID-19 patients (166 asymptomatic, 246 symptomatic and 205 hospitalised survivors) and 2 559 population-based controls.Results: We found a higher frequency of the minor allele (Tyr282) of the rs1800562 polymorphism (P < 0.002) in patients compared to controls (8.5 % vs 5.5 %). Non-carriers of the minor allele were protected against SARS-Cov-2 infection (OR, 95 %CI; 0.59, 0.42-0.82). The frequency of minor allele carriers was almost identical across asymptomatic, symptomatic, and hospitalised survivors. The rs1799945 variant did not affect disease severity and its occurrence was almost identical in patients and controls (P between 0.58 and 0.84).Conclusions: In conclusion, our results indicate that presence of the rs1800562 minor allele, which is associated with hereditary haemochromatosis (thus increased levels of plasma Fe), increases susceptibility to SARS-CoV-2.

Citovat

HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK and Ladislav DUŠEK. A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population. Clinica Chimica Acta. AMSTERDAM: ELSEVIER SCIENCE BV, 2023, vol. 538, January 2023, p. 211-215. ISSN 0009-8981. Available from: https://dx.doi.org/10.1016/j.cca.2022.12.025.

@article{2262097,
   author = {Hubacek, J. A. and Philipp, T. and Adamkova, V. and Májek, Ondřej and Dušek, Ladislav},
   article_location = {AMSTERDAM},
   article_number = {January 2023},
   doi = {http://dx.doi.org/10.1016/j.cca.2022.12.025},
   keywords = {COVID-19; HFE; Iron; Polymorphism; Susceptibility},
   language = {eng},
   issn = {0009-8981},
   journal = {Clinica Chimica Acta},
   title = {A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population},
   url = {https://www.sciencedirect.com/science/article/pii/S0009898122014279?via%3Dihub},
   volume = {538},
   year = {2023}
}

TY  - JOUR
ID  - 2262097
AU  - Hubacek, J. A. - Philipp, T. - Adamkova, V. - Májek, Ondřej - Dušek, Ladislav
PY  - 2023
TI  - A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population
JF  - Clinica Chimica Acta
VL  - 538
IS  - January 2023
SP  - 211-215
EP  - 211-215
PB  - ELSEVIER SCIENCE BV
SN  - 00098981
KW  - COVID-19
KW  - HFE
KW  - Iron
KW  - Polymorphism
KW  - Susceptibility
UR  - https://www.sciencedirect.com/science/article/pii/S0009898122014279?via%3Dihub
N2  - Background: Coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, has become a global pandemic. While susceptibility to COVID-19 is subject to several external factors, including hypertension, BMI, and the presence of diabetes, it is also genetically determined to a significant extent. Infectious agents require iron (Fe) for proper functioning. Carriers of mutations resulting in increased iron concentrations are understood to be at increased risk of COVID-19.Methods: We examined HFE genotypes associated with hereditary haemochromatosis (rs1800562 and rs1799945 SNPs) in 617 COVID-19 patients (166 asymptomatic, 246 symptomatic and 205 hospitalised survivors) and 2 559 population-based controls.Results: We found a higher frequency of the minor allele (Tyr282) of the rs1800562 polymorphism (P < 0.002) in patients compared to controls (8.5 % vs 5.5 %). Non-carriers of the minor allele were protected against SARS-Cov-2 infection (OR, 95 %CI; 0.59, 0.42-0.82). The frequency of minor allele carriers was almost identical across asymptomatic, symptomatic, and hospitalised survivors. The rs1799945 variant did not affect disease severity and its occurrence was almost identical in patients and controls (P between 0.58 and 0.84).Conclusions: In conclusion, our results indicate that presence of the rs1800562 minor allele, which is associated with hereditary haemochromatosis (thus increased levels of plasma Fe), increases susceptibility to SARS-CoV-2.
ER  -

HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK and Ladislav DUŠEK. A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population. \textit{Clinica Chimica Acta}. AMSTERDAM: ELSEVIER SCIENCE BV, 2023, vol.~538, January 2023, p.~211-215. ISSN~0009-8981. Available from: https://dx.doi.org/10.1016/j.cca.2022.12.025.

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