HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK and Ladislav DUŠEK. A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population. Clinica Chimica Acta. AMSTERDAM: ELSEVIER SCIENCE BV, 2023, vol. 538, January 2023, p. 211-215. ISSN 0009-8981. Available from: https://dx.doi.org/10.1016/j.cca.2022.12.025.
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Basic information
Original name A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population
Authors HUBACEK, J. A. (203 Czech Republic, guarantor), T. PHILIPP (203 Czech Republic), V. ADAMKOVA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution).
Edition Clinica Chimica Acta, AMSTERDAM, ELSEVIER SCIENCE BV, 2023, 0009-8981.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30230 Other clinical medicine subjects
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.000 in 2022
RIV identification code RIV/00216224:14110/23:00130381
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.cca.2022.12.025
UT WoS 000923428500001
Keywords in English COVID-19; HFE; Iron; Polymorphism; Susceptibility
Tags 14119612, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 28/2/2023 08:21.
Abstract
Background: Coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, has become a global pandemic. While susceptibility to COVID-19 is subject to several external factors, including hypertension, BMI, and the presence of diabetes, it is also genetically determined to a significant extent. Infectious agents require iron (Fe) for proper functioning. Carriers of mutations resulting in increased iron concentrations are understood to be at increased risk of COVID-19.Methods: We examined HFE genotypes associated with hereditary haemochromatosis (rs1800562 and rs1799945 SNPs) in 617 COVID-19 patients (166 asymptomatic, 246 symptomatic and 205 hospitalised survivors) and 2 559 population-based controls.Results: We found a higher frequency of the minor allele (Tyr282) of the rs1800562 polymorphism (P < 0.002) in patients compared to controls (8.5 % vs 5.5 %). Non-carriers of the minor allele were protected against SARS-Cov-2 infection (OR, 95 %CI; 0.59, 0.42-0.82). The frequency of minor allele carriers was almost identical across asymptomatic, symptomatic, and hospitalised survivors. The rs1799945 variant did not affect disease severity and its occurrence was almost identical in patients and controls (P between 0.58 and 0.84).Conclusions: In conclusion, our results indicate that presence of the rs1800562 minor allele, which is associated with hereditary haemochromatosis (thus increased levels of plasma Fe), increases susceptibility to SARS-CoV-2.
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