Prediction of Sudden Cardiac Arrest After Alcohol Septal
Ablation for Hypertrophic Obstructive Cardiomyopathy:
ASA-SCARRE Risk Score

J 2022

Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score

VESELKA, Josef, Max LIEBREGTS, Robert COOPER, Lothar FABER, Jaroslav JANUSKA et. al.

Basic information

Original name

Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score

Authors

VESELKA, Josef (203 Czech Republic, guarantor), Max LIEBREGTS, Robert COOPER, Lothar FABER, Jaroslav JANUSKA (203 Czech Republic), Maksim KASHTANOV, Klara Hulikova TESARKOVA, Peter Riis HANSEN, Hubert SEGGEWISS, Eugene SHLOYDO, Kirill POPOV, Eva HANSVENCLOVA, Eva POLAKOVA (203 Czech Republic), Jurrien Ten BERG, Rodney Hilton STABLES, Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution) and Jiri BONAVENTURA (203 Czech Republic)

Edition

American Journal of Cardiology, Bridgewater, Excerpta Medica INC-Elsevier Science INC, 2022, 0002-9149

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.800

RIV identification code

RIV/00216224:14110/22:00128732

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.amjcard.2022.08.028

UT WoS

000877775500016

Keywords in English

Alcohol Septal Ablation-Sudden Cardiac ARREst; Hypertrophic Obstructive Cardiomyopathy

Abstract

V originále

This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 +/- 14 years) who were followed up for 5.0 +/- 4.3 years (9,202 patient-years) after ASA. A total of 65 patients (3.5%) experienced sudden cardiac arrest events, translating to 0.72 events per 100 patient-years. The independent predictors of sudden cardiac arrest events were septum thickness before ASA (hazard ratio 1.09 per 1 mm, 95% confidence interval 1.04 to 1.14, p <0.001) and left ventricular outflow tract (LVOT) gradient at the last clinical checkup (hazard ratio 1.01 per 1 mm Hg, 95% confi-dence interval 1.01 to 1.02, p = 0.002). The following ASA-SCARRE risk scores were derived and independently predicted long-term risk of sudden cardiac arrest events: "0" for both LVOT gradient <30 mmHg and baseline septum thickness <20 mm; "1" for LVOT gradient >= 30 mm Hg or baseline septum thickness >= 20 mm; and "2" for both LVOT gradient >= 30 mm Hg and baseline septum thickness >= 20 mm. The C statistic of the ASA-SCARRE risk score was 0.684 (SE 0.030). In conclusion, the ASA-SCARRE risk score may be a useful and easily available clinical tool to predict risk of sudden cardiac arrest events after ASA in patients with hypertrophic obstructive cardiomyopathy. (c) 2022 Elsevier Inc. All rights reserved. (Am J Cardiol 2022;184:120-126) This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 +/- 14 years) who were followed up for 5.0 +/- 4.3 years (9,202 patient-years) after ASA. A total of 65 patients (3.5%) experienced sudden cardiac arrest events, translating to 0.72 events per 100 patient-years. The independent predictors of sudden cardiac arrest events were septum thickness before ASA (hazard ratio 1.09 per 1 mm, 95% confidence interval 1.04 to 1.14, p <0.001) and left ventricular outflow tract (LVOT) gradient at the last clinical checkup (hazard ratio 1.01 per 1 mm Hg, 95% confi-dence interval 1.01 to 1.02, p = 0.002). The following ASA-SCARRE risk scores were derived and independently predicted long-term risk of sudden cardiac arrest events: "0" for both LVOT gradient <30 mmHg and baseline septum thickness <20 mm; "1" for LVOT gradient >= 30 mm Hg or baseline septum thickness >= 20 mm; and "2" for both LVOT gradient >= 30 mm Hg and baseline septum thickness >= 20 mm. The C statistic of the ASA-SCARRE risk score was 0.684 (SE 0.030). In conclusion, the ASA-SCARRE risk score may be a useful and easily available clinical tool to predict risk of sudden cardiac arrest events after ASA in patients with hypertrophic obstructive cardiomyopathy.

Citovat

VESELKA, Josef, Max LIEBREGTS, Robert COOPER, Lothar FABER, Jaroslav JANUSKA, Maksim KASHTANOV, Klara Hulikova TESARKOVA, Peter Riis HANSEN, Hubert SEGGEWISS, Eugene SHLOYDO, Kirill POPOV, Eva HANSVENCLOVA, Eva POLAKOVA, Jurrien Ten BERG, Rodney Hilton STABLES, Jiří JARKOVSKÝ and Jiri BONAVENTURA. Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score. American Journal of Cardiology. Bridgewater: Excerpta Medica INC-Elsevier Science INC, 2022, vol. 184, December 2022, p. 120-126. ISSN 0002-9149. Available from: https://dx.doi.org/10.1016/j.amjcard.2022.08.028.

@article{2262098,
   author = {Veselka, Josef and Liebregts, Max and Cooper, Robert and Faber, Lothar and Januska, Jaroslav and Kashtanov, Maksim and Tesarkova, Klara Hulikova and Hansen, Peter Riis and Seggewiss, Hubert and Shloydo, Eugene and Popov, Kirill and Hansvenclova, Eva and Polakova, Eva and Berg, Jurrien Ten and Stables, Rodney Hilton and Jarkovský, Jiří and Bonaventura, Jiri},
   article_location = {Bridgewater},
   article_number = {December 2022},
   doi = {http://dx.doi.org/10.1016/j.amjcard.2022.08.028},
   keywords = {Alcohol Septal Ablation-Sudden Cardiac ARREst; Hypertrophic Obstructive Cardiomyopathy},
   language = {eng},
   issn = {0002-9149},
   journal = {American Journal of Cardiology},
   title = {Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score},
   url = {https://www.sciencedirect.com/science/article/pii/S0002914922009109?via%3Dihub},
   volume = {184},
   year = {2022}
}

TY  - JOUR
ID  - 2262098
AU  - Veselka, Josef - Liebregts, Max - Cooper, Robert - Faber, Lothar - Januska, Jaroslav - Kashtanov, Maksim - Tesarkova, Klara Hulikova - Hansen, Peter Riis - Seggewiss, Hubert - Shloydo, Eugene - Popov, Kirill - Hansvenclova, Eva - Polakova, Eva - Berg, Jurrien Ten - Stables, Rodney Hilton - Jarkovský, Jiří - Bonaventura, Jiri
PY  - 2022
TI  - Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score
JF  - American Journal of Cardiology
VL  - 184
IS  - December 2022
SP  - 120-126
EP  - 120-126
PB  - Excerpta Medica INC-Elsevier Science INC
SN  - 00029149
KW  - Alcohol Septal Ablation-Sudden Cardiac ARREst
KW  - Hypertrophic Obstructive Cardiomyopathy
UR  - https://www.sciencedirect.com/science/article/pii/S0002914922009109?via%3Dihub
N2  - This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 +/- 14 years) who were followed up for 5.0 +/- 4.3 years (9,202 patient-years) after ASA. A total of 65 patients (3.5%) experienced sudden cardiac arrest events, translating to 0.72 events per 100 patient-years. The independent predictors of sudden cardiac arrest events were septum thickness before ASA (hazard ratio 1.09 per 1 mm, 95% confidence interval 1.04 to 1.14, p <0.001) and left ventricular outflow tract (LVOT) gradient at the last clinical checkup (hazard ratio 1.01 per 1 mm Hg, 95% confi-dence interval 1.01 to 1.02, p = 0.002). The following ASA-SCARRE risk scores were derived and independently predicted long-term risk of sudden cardiac arrest events: "0" for both LVOT gradient <30 mmHg and baseline septum thickness <20 mm; "1" for LVOT gradient >= 30 mm Hg or baseline septum thickness >= 20 mm; and "2" for both LVOT gradient >= 30 mm Hg and baseline septum thickness >= 20 mm. The C statistic of the ASA-SCARRE risk score was 0.684 (SE 0.030). In conclusion, the ASA-SCARRE risk score may be a useful and easily available clinical tool to predict risk of sudden cardiac arrest events after ASA in patients with hypertrophic obstructive cardiomyopathy. (c) 2022 Elsevier Inc. All rights reserved. (Am J Cardiol 2022;184:120-126) This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 +/- 14 years) who were followed up for 5.0 +/- 4.3 years (9,202 patient-years) after ASA. A total of 65 patients (3.5%) experienced sudden cardiac arrest events, translating to 0.72 events per 100 patient-years. The independent predictors of sudden cardiac arrest events were septum thickness before ASA (hazard ratio 1.09 per 1 mm, 95% confidence interval 1.04 to 1.14, p <0.001) and left ventricular outflow tract (LVOT) gradient at the last clinical checkup (hazard ratio 1.01 per 1 mm Hg, 95% confi-dence interval 1.01 to 1.02, p = 0.002). The following ASA-SCARRE risk scores were derived and independently predicted long-term risk of sudden cardiac arrest events: "0" for both LVOT gradient <30 mmHg and baseline septum thickness <20 mm; "1" for LVOT gradient >= 30 mm Hg or baseline septum thickness >= 20 mm; and "2" for both LVOT gradient >= 30 mm Hg and baseline septum thickness >= 20 mm. The C statistic of the ASA-SCARRE risk score was 0.684 (SE 0.030). In conclusion, the ASA-SCARRE risk score may be a useful and easily available clinical tool to predict risk of sudden cardiac arrest events after ASA in patients with hypertrophic obstructive cardiomyopathy.
ER  -

VESELKA, Josef, Max LIEBREGTS, Robert COOPER, Lothar FABER, Jaroslav JANUSKA, Maksim KASHTANOV, Klara Hulikova TESARKOVA, Peter Riis HANSEN, Hubert SEGGEWISS, Eugene SHLOYDO, Kirill POPOV, Eva HANSVENCLOVA, Eva POLAKOVA, Jurrien Ten BERG, Rodney Hilton STABLES, Jiří JARKOVSKÝ and Jiri BONAVENTURA. Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score. \textit{American Journal of Cardiology}. Bridgewater: Excerpta Medica INC-Elsevier Science INC, 2022, vol.~184, December 2022, p.~120-126. ISSN~0002-9149. Available from: https://dx.doi.org/10.1016/j.amjcard.2022.08.028.

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