The amount of preoperative endometrial tissue surface in
relation to final endometrial cancer classification

J 2022

The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification

VREDE, S.W., A.M.C. HULSMAN, C. REIJNEN, K. VAN DE VIJVER, E. COLAS et. al.

Basic information

Original name

The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification

Authors

VREDE, S.W. (guarantor), A.M.C. HULSMAN, C. REIJNEN, K. VAN DE VIJVER, E. COLAS, G. MANCEBO, C.P. MOIOLA, A. GIL-MORENO, J. HUVILA, M. KOSKAS, Vít WEINBERGER (203 Czech Republic, belonging to the institution), Luboš MINÁŘ (203 Czech Republic, belonging to the institution), Eva JANDÁKOVÁ (203 Czech Republic, belonging to the institution), M. SANTACANA, X. MATIAS-GUIU, F. AMANT, M.P.L.M. SNIJDERS, H.V.N. KÜSTERS-VANDEVELDE, J. BULTEN and J.M.A. PIJNENBORG

Edition

Gynecologic oncology, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, 0090-8258

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.700

RIV identification code

RIV/00216224:14110/22:00128746

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ygyno.2022.08.016

UT WoS

000929667200010

Keywords in English

Endometrial carcinoma; Diagnosis; Concordant; Discordant; Pathology; Endometrial sampling

Abstract

V originále

Objective To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling method and impacts outcome. Methods A retrospective cohort study within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC). Surface of preoperative endometrial tissue samples was digitally calculated using ImageJ. Tumor samples were classified into low-grade (grade 1–2 endometrioid EC (EEC)) and high-grade (grade 3 EEC + non-endometroid EC). Results The study cohort included 573 tumor samples. Overall concordance between pre- and postoperative diagnosis was 60.0%, and 88.8% when classified into low- and high-grade EC. Upgrading (preoperative low-grade, postoperative high-grade EC) was found in 7.8% and downgrading (preoperative high-grade, postoperative low-grade EC) in 26.7%. The median endometrial tissue surface was significantly lower in concordant diagnoses when compared to discordant diagnoses, respectively 18.7 mm2 and 23.5 mm2 (P = 0.022). Sampling method did not influence the concordance in tumor classification. Patients with preoperative high-grade and postoperative low-grade showed significant lower DSS compared to patients with concordant low-grade EC (P = 0.039). Conclusion The amount of preoperative endometrial tissue surface was inversely related to the degree of concordance with final tumor low- and high-grade. Obtaining higher amount of preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC. Awareness of clinically relevant down- and upgrading is crucial to reduce subsequent over- or undertreatment with impact on outcome.

Citovat

VREDE, S.W., A.M.C. HULSMAN, C. REIJNEN, K. VAN DE VIJVER, E. COLAS, G. MANCEBO, C.P. MOIOLA, A. GIL-MORENO, J. HUVILA, M. KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, M. SANTACANA, X. MATIAS-GUIU, F. AMANT, M.P.L.M. SNIJDERS, H.V.N. KÜSTERS-VANDEVELDE, J. BULTEN and J.M.A. PIJNENBORG. The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification. Gynecologic oncology. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, vol. 167, No 2, p. 196-204. ISSN 0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2022.08.016.

@article{2262357,
   author = {Vrede, S.W. and Hulsman, A.M.C. and Reijnen, C. and Van de Vijver, K. and Colas, E. and Mancebo, G. and Moiola, C.P. and GilandMoreno, A. and Huvila, J. and Koskas, M. and Weinberger, Vít and Minář, Luboš and Jandáková, Eva and Santacana, M. and MatiasandGuiu, X. and Amant, F. and Snijders, M.P.L.M. and KüstersandVandevelde, H.V.N. and Bulten, J. and Pijnenborg, J.M.A.},
   article_location = {SAN DIEGO},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.ygyno.2022.08.016},
   keywords = {Endometrial carcinoma; Diagnosis; Concordant; Discordant; Pathology; Endometrial sampling},
   language = {eng},
   issn = {0090-8258},
   journal = {Gynecologic oncology},
   title = {The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification},
   url = {https://www.sciencedirect.com/science/article/pii/S0090825822005704?via%3Dihub},
   volume = {167},
   year = {2022}
}

TY  - JOUR
ID  - 2262357
AU  - Vrede, S.W. - Hulsman, A.M.C. - Reijnen, C. - Van de Vijver, K. - Colas, E. - Mancebo, G. - Moiola, C.P. - Gil-Moreno, A. - Huvila, J. - Koskas, M. - Weinberger, Vít - Minář, Luboš - Jandáková, Eva - Santacana, M. - Matias-Guiu, X. - Amant, F. - Snijders, M.P.L.M. - Küsters-Vandevelde, H.V.N. - Bulten, J. - Pijnenborg, J.M.A.
PY  - 2022
TI  - The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification
JF  - Gynecologic oncology
VL  - 167
IS  - 2
SP  - 196-204
EP  - 196-204
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00908258
KW  - Endometrial carcinoma
KW  - Diagnosis
KW  - Concordant
KW  - Discordant
KW  - Pathology
KW  - Endometrial sampling
UR  - https://www.sciencedirect.com/science/article/pii/S0090825822005704?via%3Dihub
N2  - Objective To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling method and impacts outcome. Methods A retrospective cohort study within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC). Surface of preoperative endometrial tissue samples was digitally calculated using ImageJ. Tumor samples were classified into low-grade (grade 1–2 endometrioid EC (EEC)) and high-grade (grade 3 EEC + non-endometroid EC). Results The study cohort included 573 tumor samples. Overall concordance between pre- and postoperative diagnosis was 60.0%, and 88.8% when classified into low- and high-grade EC. Upgrading (preoperative low-grade, postoperative high-grade EC) was found in 7.8% and downgrading (preoperative high-grade, postoperative low-grade EC) in 26.7%. The median endometrial tissue surface was significantly lower in concordant diagnoses when compared to discordant diagnoses, respectively 18.7 mm2 and 23.5 mm2 (P = 0.022). Sampling method did not influence the concordance in tumor classification. Patients with preoperative high-grade and postoperative low-grade showed significant lower DSS compared to patients with concordant low-grade EC (P = 0.039). Conclusion The amount of preoperative endometrial tissue surface was inversely related to the degree of concordance with final tumor low- and high-grade. Obtaining higher amount of preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC. Awareness of clinically relevant down- and upgrading is crucial to reduce subsequent over- or undertreatment with impact on outcome.
ER  -

VREDE, S.W., A.M.C. HULSMAN, C. REIJNEN, K. VAN DE VIJVER, E. COLAS, G. MANCEBO, C.P. MOIOLA, A. GIL-MORENO, J. HUVILA, M. KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, M. SANTACANA, X. MATIAS-GUIU, F. AMANT, M.P.L.M. SNIJDERS, H.V.N. KÜSTERS-VANDEVELDE, J. BULTEN and J.M.A. PIJNENBORG. The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification. \textit{Gynecologic oncology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, vol.~167, No~2, p.~196-204. ISSN~0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2022.08.016.

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