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@article{2262380,
author = {Muresan, Ximena M. and Slabáková, Eva and Procházková, Jiřina and Drápela, Stanislav and Fedr, Radek and Pícková, Markéta and Vacek, Ondřej and Víchová, Ráchel and Suchánková, Tereza and Bouchal, Jan and Kürfürstová, Daniela and Král, Milan and Hulínová, Tereza and Sýkora, Radek P. and Študent, Vladimír and Hejret, Václav and van Weerden, Wytske M. and Puhr, Martin and Pustka, Václav and Potěšil, David and Zdráhal, Zbyněk and Culig, Zoran and Souček, Karel},
article_number = {9},
doi = {http://dx.doi.org/10.1016/j.ajpath.2022.05.009},
keywords = {prostate cancer; PCa; toll-like receptor; TLR3; resistance; chemotherapy; endocrine therapy},
language = {eng},
issn = {0002-9440},
journal = {American Journal of Pathology},
title = {Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis},
url = {https://doi.org/10.1016/j.ajpath.2022.05.009},
volume = {192},
year = {2022}
}
TY - JOUR
ID - 2262380
AU - Muresan, Ximena M. - Slabáková, Eva - Procházková, Jiřina - Drápela, Stanislav - Fedr, Radek - Pícková, Markéta - Vacek, Ondřej - Víchová, Ráchel - Suchánková, Tereza - Bouchal, Jan - Kürfürstová, Daniela - Král, Milan - Hulínová, Tereza - Sýkora, Radek P. - Študent, Vladimír - Hejret, Václav - van Weerden, Wytske M. - Puhr, Martin - Pustka, Václav - Potěšil, David - Zdráhal, Zbyněk - Culig, Zoran - Souček, Karel
PY - 2022
TI - Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis
JF - American Journal of Pathology
VL - 192
IS - 9
SP - 1321-1335
EP - 1321-1335
PB - Elsevier
SN - 00029440
KW - prostate cancer
KW - PCa
KW - toll-like receptor
KW - TLR3
KW - resistance
KW - chemotherapy
KW - endocrine therapy
UR - https://doi.org/10.1016/j.ajpath.2022.05.009
N2 - Toll-like receptor 3 (TLR3) is an endosomal receptor expressed in several immune and epithelial cells. Recent studies have highlighted its expression also in solid tumors, including prostate cancer (PCa), and have described its role primarily in the proinflammatory response and induction of apoptosis. It is up-regulated in some castration-resistant prostate cancers. However, the role of TLR3 in prostate cancer progression remains largely unknown. The current study experimentally demonstrated that exogenous TLR3 activation in PCa cell lines leads to a significant induction of secretion of the cytokines IL-6, IL-8, and interferon-β, depending on the model and chemoresistance status. Transcriptomic analysis of TLR3-overexpressing cells revealed a functional program that is enriched for genes involved in the regulation of cell motility, migration, and tumor invasiveness. Increased motility, migration, and invasion in TLR3-overexpressing cell line were confirmed by several in vitro assays and using an orthotopic prostate xenograft model in vivo. Furthermore, TLR3-ligand induced apoptosis via cleavage of caspase-3/7 and poly (ADP-ribose) polymerase, predominantly in TLR3-overexpressing cells. These results indicate that TLR3 may be involved in prostate cancer progression and metastasis; however, it might also represent an Achilles heel of PCa, which can be exploited for targeted therapy.
ER -
MURESAN, Ximena M., Eva SLABÁKOVÁ, Jiřina PROCHÁZKOVÁ, Stanislav DRÁPELA, Radek FEDR, Markéta PÍCKOVÁ, Ondřej VACEK, Ráchel VÍCHOVÁ, Tereza SUCHÁNKOVÁ, Jan BOUCHAL, Daniela KÜRFÜRSTOVÁ, Milan KRÁL, Tereza HULÍNOVÁ, Radek P. SÝKORA, Vladimír ŠTUDENT, Václav HEJRET, Wytske M. VAN WEERDEN, Martin PUHR, Václav PUSTKA, David POTĚŠIL, Zbyněk ZDRÁHAL, Zoran CULIG and Karel SOUČEK. Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis. \textit{American Journal of Pathology}. Elsevier, 2022, vol.~192, No~9, p.~1321-1335. ISSN~0002-9440. Available from: https://dx.doi.org/10.1016/j.ajpath.2022.05.009.
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