| FENCLOVÁ, Tereza, Marouane CHEMEK, Jiřina HAVRÁNKOVÁ, Yaroslav KOLINKO, Vendula SUDOVÁ, Jiří MORAVEC, Jana NAVRÁTILOVÁ, Pavel KLEIN, Milena KRÁLÍČKOVÁ and Jan NEVORAL. Effect of Bisphenol S on testicular tissue after low-dose lactation exposure. Environmental Pollution. Elsevier, 2022, vol. 315, December 2022, p. 1-11. ISSN 0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2022.120114. |
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@article{2262801,
author = {Fenclová, Tereza and Chemek, Marouane and Havránková, Jiřina and Kolinko, Yaroslav and Sudová, Vendula and Moravec, Jiří and Navrátilová, Jana and Klein, Pavel and Králíčková, Milena and Nevoral, Jan},
article_number = {December 2022},
doi = {http://dx.doi.org/10.1016/j.envpol.2022.120114},
keywords = {Bisphenol S; Idiopathic infertility; Lactation exposure; Testicular tissue; Blood -testis barrier; Oxidative stress},
language = {eng},
issn = {0269-7491},
journal = {Environmental Pollution},
title = {Effect of Bisphenol S on testicular tissue after low-dose lactation exposure},
url = {https://doi.org/10.1016/j.envpol.2022.120114},
volume = {315},
year = {2022}
}
TY - JOUR
ID - 2262801
AU - Fenclová, Tereza - Chemek, Marouane - Havránková, Jiřina - Kolinko, Yaroslav - Sudová, Vendula - Moravec, Jiří - Navrátilová, Jana - Klein, Pavel - Králíčková, Milena - Nevoral, Jan
PY - 2022
TI - Effect of Bisphenol S on testicular tissue after low-dose lactation exposure
JF - Environmental Pollution
VL - 315
IS - December 2022
SP - 1-11
EP - 1-11
PB - Elsevier
SN - 02697491
KW - Bisphenol S
KW - Idiopathic infertility
KW - Lactation exposure
KW - Testicular tissue
KW - Blood -testis barrier
KW - Oxidative stress
UR - https://doi.org/10.1016/j.envpol.2022.120114
N2 - Exposure to endocrine disruptors such as bisphenols, can lead to and be the explanation for idiopathic infertility. In our study, we assessed the effect of exposure to bisphenol S (BPS) via breast milk on the testicular tissue health of adult male mice. Lactating dams were exposed to BPS through drinking water (0.216 ng g bw/day and 21.6 ng g bw/day) from post-natal day 0–15. Although there was no significant difference in testicular histopathology between the control and experimental groups, we observed an increase in the number of tight and gap junctions in the blood-testis barrier (BTB) of adult mice after lactation BPS exposure. Moreover, there was an increase in oxidative stress markers in adult testicular tissue of mice exposed via breast milk. Our lactation model indicates that breast milk is a route of exposure to an endocrine disruptor that can be responsible for idiopathic male infertility through the damage of the BTB and weakening of oxidative stress resistance in adulthood.
ER -
FENCLOVÁ, Tereza, Marouane CHEMEK, Jiřina HAVRÁNKOVÁ, Yaroslav KOLINKO, Vendula SUDOVÁ, Jiří MORAVEC, Jana NAVRÁTILOVÁ, Pavel KLEIN, Milena KRÁLÍČKOVÁ and Jan NEVORAL. Effect of Bisphenol S on testicular tissue after low-dose lactation exposure. \textit{Environmental Pollution}. Elsevier, 2022, vol.~315, December 2022, p.~1-11. ISSN~0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2022.120114.
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