J 2022

Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy

ZLÍNSKÁ, Vladimíra, Vaclav MATOUSEK, Lukáš TRANTÍREK and Riccardo RIGO

Basic information

Original name

Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy

Authors

ZLÍNSKÁ, Vladimíra (203 Czech Republic, belonging to the institution), Vaclav MATOUSEK, Lukáš TRANTÍREK (203 Czech Republic, belonging to the institution) and Riccardo RIGO (380 Italy, belonging to the institution)

Edition

ALDRICHIMICA ACTA, UNITED STATES, ALDRICH CHEMICAL CO INC, 2022, 0002-5100

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.600

RIV identification code

RIV/00216224:14740/22:00128812

Organization unit

Central European Institute of Technology

UT WoS

000923599400003

Keywords in English

F-19 NMR spectroscopy; F-19 probes; DNA; RNA; F-19-labeling approaches; nucleic acid folding; nucleic acid/small molecule interactions; nucleic acid/protein interactions; in vitro; in vivo

Tags

Tags

International impact, Reviewed
Změněno: 8/3/2023 09:36, Mgr. Pavla Foltynová, Ph.D.

Abstract

V originále

This mini-review provides an overview of approaches to F-19-labeling of nucleic acids. A special attention is paid to applications of F-19-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.

Links

EF20_079/0017045, research and development project
Name: MSCAfellow4@MUNI
NV19-08-00450, research and development project
Name: Atomárně rozlišená NMR spektroskopie in vivo jako nástroj pro biologické testování terapeuticky významných cílů v genomové ne-kanonické DNA a jejich interakcí s léčivy ve fenotypově diverzifikovaných nádorových buňkách.
Investor: Ministry of Health of the CR