Detailed Information on Publication Record
2023
Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension
NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Jana MARKOVA, Alice MARTINKOVICOVA, Zuzana KOSUTZKA et. al.Basic information
Original name
Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension
Authors
NOVÁKOVÁ, Ľubomíra (703 Slovakia, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution), Jana MARKOVA (703 Slovakia), Alice MARTINKOVICOVA (703 Slovakia), Zuzana KOSUTZKA (703 Slovakia), Jana SVANTNEROVA (703 Slovakia), Peter VALKOVIC (703 Slovakia), Cséfalvay ZSOLT (703 Slovakia) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Frontiers in aging neuroscience, LAUSANNE, FRONTIERS MEDIA SA, 2023, 1663-4365
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.800 in 2022
RIV identification code
RIV/00216224:14740/23:00130414
Organization unit
Central European Institute of Technology
UT WoS
000951311600001
Keywords in English
Parkinson’s disease; language impairment; sentence reading comprehension; task fMRI; functional connectivity; striatum
Tags
International impact, Reviewed
Změněno: 17/10/2024 08:58, Mgr. Adéla Pešková
Abstract
V originále
Parkinson’s disease (PD) affects the language processes, with a significant impact on the patients’ daily communication. We aimed to describe specific alterations in the comprehension of syntactically complex sentences in patients with PD (PwPD) as compared to healthy controls (HC) and to identify the neural underpinnings of these deficits using a functional connectivity analysis of the striatum. A total of 20 patients PwPD and 15 HC participated in the fMRI study. We analyzed their performance of a Test of sentence comprehension (ToSC) adjusted for fMRI. A task-dependent functional connectivity analysis of the striatum was conducted using the psychophysiological interaction method (PPI). On the behavioral level, the PwPD scored significantly lower (mean sd: 77.3 12.6) in the total ToSC score than the HC did (mean sd: 86.6 8.0), p = 0.02, and the difference was also significant specifically for sentences with a noncanonical word order (PD-mean sd: 69.9 14.1, HC-mean sd: 80.2 11.5, p = 0.04). Using PPI, we found a statistically significant difference between the PwPD and the HC in connectivity from the right striatum to the supplementary motor area [SMA, (4 8 53)] for non-canonical sentences. This PPI connectivity was negatively correlated with the ToSC accuracy of non-canonical sentences in the PwPD. Our results showed disturbed sentence reading comprehension in the PwPD with altered task-dependent functional connectivity from the right striatum to the SMA, which supports the synchronization of the temporal and sequential aspects of language processing. The study revealed that subcorticalcortical networks (striatal-frontal loop) in PwPD are compromised, leading to impaired comprehension of syntactically complex sentences.
Links
| 90129, large research infrastructures |
|