| MARTINO, Fabiana, Nandan Mysore VARADARAJAN, Ana Rubina PERESTRELO, Václav HEJRET, Helena DURIKOVA, Dragana VUKIĆ, Vladimir HORVATH, Francesca CAVALIERI, Frank CARUSO, Waleed S ALBIHLAL, Andre P GERBER, Mary Anne O'CONNELL, Štěpánka VAŇÁČOVÁ, Stefania PAGLIARI and Giancarlo FORTE. The mechanical regulation of RNA binding protein hnRNPC in the failing heart. Science Translational Medicine. Washington: American Association for the Advancement of Science, 2022, vol. 14, No 672, p. 1-17. ISSN 1946-6234. Available from: https://dx.doi.org/10.1126/scitranslmed.abo5715. |
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@article{2265424,
author = {Martino, Fabiana and Varadarajan, Nandan Mysore and Perestrelo, Ana Rubina and Hejret, Václav and Durikova, Helena and Vukić, Dragana and Horvath, Vladimir and Cavalieri, Francesca and Caruso, Frank and Albihlal, Waleed S and Gerber, Andre P and O'Connell, Mary Anne and Vaňáčová, Štěpánka and Pagliari, Stefania and Forte, Giancarlo},
article_location = {Washington},
article_number = {672},
doi = {http://dx.doi.org/10.1126/scitranslmed.abo5715},
keywords = {Extracellular Matrix; Heart Failure; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans},
language = {eng},
issn = {1946-6234},
journal = {Science Translational Medicine},
title = {The mechanical regulation of RNA binding protein hnRNPC in the failing heart},
url = {https://www.science.org/doi/10.1126/scitranslmed.abo5715},
volume = {14},
year = {2022}
}
TY - JOUR
ID - 2265424
AU - Martino, Fabiana - Varadarajan, Nandan Mysore - Perestrelo, Ana Rubina - Hejret, Václav - Durikova, Helena - Vukić, Dragana - Horvath, Vladimir - Cavalieri, Francesca - Caruso, Frank - Albihlal, Waleed S - Gerber, Andre P - O'Connell, Mary Anne - Vaňáčová, Štěpánka - Pagliari, Stefania - Forte, Giancarlo
PY - 2022
TI - The mechanical regulation of RNA binding protein hnRNPC in the failing heart
JF - Science Translational Medicine
VL - 14
IS - 672
SP - 1-17
EP - 1-17
PB - American Association for the Advancement of Science
SN - 19466234
KW - Extracellular Matrix
KW - Heart Failure
KW - Heterogeneous-Nuclear Ribonucleoprotein Group C
KW - Humans
UR - https://www.science.org/doi/10.1126/scitranslmed.abo5715
N2 - Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failure. Cardiomyocytes respond to the ensuing biomechanical stress by reexpressing fetal contractile proteins via transcriptional and posttranscriptional processes, such as alternative splicing (AS). Here, we demonstrate that the heterogeneous nuclear ribonucleoprotein C (hnRNPC) is up-regulated and relocates to the sarcomeric Z-disc upon ECM pathological remodeling. We show that this is an active site of localized translation, where the ribonucleoprotein associates with the translation machinery. Alterations in hnRNPC expression, phosphorylation, and localization can be mechanically determined and affect the AS of mRNAs involved in mechanotransduction and cardiovascular diseases, including Hippo pathway effector Yes-associated protein 1. We propose that cardiac ECM remodeling serves as a switch in RNA metabolism by affecting an associated regulatory protein of the spliceosome apparatus. These findings offer new insights on the mechanism of mRNA homeostatic mechanoregulation in pathological conditions.
ER -
MARTINO, Fabiana, Nandan Mysore VARADARAJAN, Ana Rubina PERESTRELO, Václav HEJRET, Helena DURIKOVA, Dragana VUKI$\backslash$'C, Vladimir HORVATH, Francesca CAVALIERI, Frank CARUSO, Waleed S ALBIHLAL, Andre P GERBER, Mary Anne O'CONNELL, Štěpánka VAŇÁČOVÁ, Stefania PAGLIARI and Giancarlo FORTE. The mechanical regulation of RNA binding protein hnRNPC in the failing heart. \textit{Science Translational Medicine}. Washington: American Association for the Advancement of Science, 2022, vol.~14, No~672, p.~1-17. ISSN~1946-6234. Available from: https://dx.doi.org/10.1126/scitranslmed.abo5715.
|
