| ANDREAKOS, Evangelos, Laurent ABEL, Donald C VINH, Elzbieta KAJA, Beth A DROLET, Qian ZHANG, Cliona FARRELLY, Giuseppe NOVELLI, Carlos RODRIGUEZ-GALLEGO, Filomeen HAERYNCK, Carolina PRANDO, Aurora PUJOL, Helen C SU, Jean-Laurent CASANOVA, Andras N SPAAN, Paul BASTARD, Catherine M BIGGS, Benedetta BIGIO, Bertrand BOISSON, Alexandre BOLZE, Anastasiia BONDARENKO, Petter BRODIN, Samya CHAKRAVORTY, John CHRISTODOULOU, Aurelie COBAT, Antonio CONDINO-NETO, Stefan N CONSTANTINESCU, Hagit Baris FELDMAN, Jacques FELLAY, Rabih HALWANI, Emmanuelle JOUANGUY, Yu-Lung LAU, Isabelle MEYTS, Trine H MOGENSEN, Satoshi OKADA, Keisuke OKAMOTO, Tayfun OZCELIK, Qiang PAN-HAMMARSTROM, Anna M PLANAS, Anne PUEL, Lluis QUINTANA-MURCI, Laurent RENIA, Igor RESNICK, Anna SEDIVA, Anna SHCHERBINA, Ondřej SLABÝ, Ivan TANCEVSKI, Stuart E TURVEY, K M Furkan UDDIN, van de Beek DIEDERIK, Mayana ZATZ, Pawel ZAWADZKI and Shen-Ying ZHANG. A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. Nature immunology. 2022, vol. 23, No 2, p. 159-164. ISSN 1529-2908. Available from: https://dx.doi.org/10.1038/s41590-021-01030-z. |
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@article{2265639,
author = {Andreakos, Evangelos and Abel, Laurent and Vinh, Donald C and Kaja, Elzbieta and Drolet, Beth A and Zhang, Qian and Farrelly, Cliona and Novelli, Giuseppe and RodriguezandGallego, Carlos and Haerynck, Filomeen and Prando, Carolina and Pujol, Aurora and Su, Helen C and Casanova, JeanandLaurent and Spaan, Andras N and Bastard, Paul and Biggs, Catherine M and Bigio, Benedetta and Boisson, Bertrand and Bolze, Alexandre and Bondarenko, Anastasiia and Brodin, Petter and Chakravorty, Samya and Christodoulou, John and Cobat, Aurelie and CondinoandNeto, Antonio and Constantinescu, Stefan N and Feldman, Hagit Baris and Fellay, Jacques and Halwani, Rabih and Jouanguy, Emmanuelle and Lau, YuandLung and Meyts, Isabelle and Mogensen, Trine H and Okada, Satoshi and Okamoto, Keisuke and Ozcelik, Tayfun and PanandHammarstrom, Qiang and Planas, Anna M and Puel, Anne and QuintanaandMurci, Lluis and Renia, Laurent and Resnick, Igor and Sediva, Anna and Shcherbina, Anna and Slabý, Ondřej and Tancevski, Ivan and Turvey, Stuart E and Uddin, K M Furkan and Diederik, van de Beek and Zatz, Mayana and Zawadzki, Pawel and Zhang, ShenandYing},
article_number = {2},
doi = {http://dx.doi.org/10.1038/s41590-021-01030-z},
keywords = {Animals; COVID-19; Disease Resistance; Genetic Heterogeneity; Genetic Predisposition to Disease; Host-Pathogen Interactions; Humans; Phenotype; Protective Factors; Risk Assessment; Risk Factors; SARS-CoV-2},
language = {eng},
issn = {1529-2908},
journal = {Nature immunology},
title = {A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection},
url = {https://www.nature.com/articles/s41590-021-01030-z},
volume = {23},
year = {2022}
}
TY - JOUR
ID - 2265639
AU - Andreakos, Evangelos - Abel, Laurent - Vinh, Donald C - Kaja, Elzbieta - Drolet, Beth A - Zhang, Qian - Farrelly, Cliona - Novelli, Giuseppe - Rodriguez-Gallego, Carlos - Haerynck, Filomeen - Prando, Carolina - Pujol, Aurora - Su, Helen C - Casanova, Jean-Laurent - Spaan, Andras N - Bastard, Paul - Biggs, Catherine M - Bigio, Benedetta - Boisson, Bertrand - Bolze, Alexandre - Bondarenko, Anastasiia - Brodin, Petter - Chakravorty, Samya - Christodoulou, John - Cobat, Aurelie - Condino-Neto, Antonio - Constantinescu, Stefan N - Feldman, Hagit Baris - Fellay, Jacques - Halwani, Rabih - Jouanguy, Emmanuelle - Lau, Yu-Lung - Meyts, Isabelle - Mogensen, Trine H - Okada, Satoshi - Okamoto, Keisuke - Ozcelik, Tayfun - Pan-Hammarstrom, Qiang - Planas, Anna M - Puel, Anne - Quintana-Murci, Lluis - Renia, Laurent - Resnick, Igor - Sediva, Anna - Shcherbina, Anna - Slabý, Ondřej - Tancevski, Ivan - Turvey, Stuart E - Uddin, K M Furkan - Diederik, van de Beek - Zatz, Mayana - Zawadzki, Pawel - Zhang, Shen-Ying
PY - 2022
TI - A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
JF - Nature immunology
VL - 23
IS - 2
SP - 159-164
EP - 159-164
SN - 15292908
KW - Animals
KW - COVID-19
KW - Disease Resistance
KW - Genetic Heterogeneity
KW - Genetic Predisposition to Disease
KW - Host-Pathogen Interactions
KW - Humans
KW - Phenotype
KW - Protective Factors
KW - Risk Assessment
KW - Risk Factors
KW - SARS-CoV-2
UR - https://www.nature.com/articles/s41590-021-01030-z
N2 - SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
ER -
ANDREAKOS, Evangelos, Laurent ABEL, Donald C VINH, Elzbieta KAJA, Beth A DROLET, Qian ZHANG, Cliona FARRELLY, Giuseppe NOVELLI, Carlos RODRIGUEZ-GALLEGO, Filomeen HAERYNCK, Carolina PRANDO, Aurora PUJOL, Helen C SU, Jean-Laurent CASANOVA, Andras N SPAAN, Paul BASTARD, Catherine M BIGGS, Benedetta BIGIO, Bertrand BOISSON, Alexandre BOLZE, Anastasiia BONDARENKO, Petter BRODIN, Samya CHAKRAVORTY, John CHRISTODOULOU, Aurelie COBAT, Antonio CONDINO-NETO, Stefan N CONSTANTINESCU, Hagit Baris FELDMAN, Jacques FELLAY, Rabih HALWANI, Emmanuelle JOUANGUY, Yu-Lung LAU, Isabelle MEYTS, Trine H MOGENSEN, Satoshi OKADA, Keisuke OKAMOTO, Tayfun OZCELIK, Qiang PAN-HAMMARSTROM, Anna M PLANAS, Anne PUEL, Lluis QUINTANA-MURCI, Laurent RENIA, Igor RESNICK, Anna SEDIVA, Anna SHCHERBINA, Ondřej SLABÝ, Ivan TANCEVSKI, Stuart E TURVEY, K M Furkan UDDIN, van de Beek DIEDERIK, Mayana ZATZ, Pawel ZAWADZKI and Shen-Ying ZHANG. A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. \textit{Nature immunology}. 2022, vol.~23, No~2, p.~159-164. ISSN~1529-2908. Available from: https://dx.doi.org/10.1038/s41590-021-01030-z.
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