J 2022

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

ANDREAKOS, Evangelos, Laurent ABEL, Donald C VINH, Elzbieta KAJA, Beth A DROLET et. al.

Basic information

Original name

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Authors

ANDREAKOS, Evangelos, Laurent ABEL, Donald C VINH, Elzbieta KAJA, Beth A DROLET, Qian ZHANG, Cliona FARRELLY, Giuseppe NOVELLI, Carlos RODRIGUEZ-GALLEGO, Filomeen HAERYNCK, Carolina PRANDO, Aurora PUJOL, Helen C SU, Jean-Laurent CASANOVA, Andras N SPAAN, Paul BASTARD, Catherine M BIGGS, Benedetta BIGIO, Bertrand BOISSON, Alexandre BOLZE, Anastasiia BONDARENKO, Petter BRODIN, Samya CHAKRAVORTY, John CHRISTODOULOU, Aurelie COBAT, Antonio CONDINO-NETO, Stefan N CONSTANTINESCU, Hagit Baris FELDMAN, Jacques FELLAY, Rabih HALWANI, Emmanuelle JOUANGUY, Yu-Lung LAU, Isabelle MEYTS, Trine H MOGENSEN, Satoshi OKADA, Keisuke OKAMOTO, Tayfun OZCELIK, Qiang PAN-HAMMARSTROM, Anna M PLANAS, Anne PUEL, Lluis QUINTANA-MURCI, Laurent RENIA, Igor RESNICK, Anna SEDIVA, Anna SHCHERBINA, Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution), Ivan TANCEVSKI, Stuart E TURVEY, K M Furkan UDDIN, van de Beek DIEDERIK, Mayana ZATZ, Pawel ZAWADZKI and Shen-Ying ZHANG

Edition

Nature immunology, 2022, 1529-2908

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 30.500

RIV identification code

RIV/00216224:14740/22:00128828

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41590-021-01030-z

UT WoS

000708815900001

Keywords in English

Animals; COVID-19; Disease Resistance; Genetic Heterogeneity; Genetic Predisposition to Disease; Host-Pathogen Interactions; Humans; Phenotype; Protective Factors; Risk Assessment; Risk Factors; SARS-CoV-2

Tags

14110513, podil, rivok

Tags

International impact, Reviewed
Změněno: 8/3/2023 19:37, Mgr. Pavla Foltynová, Ph.D.

Abstract

V originále

SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
Displayed: 4/11/2024 06:37