MELICHAROVÁ, Jana, Tereza KAUEROVÁ, Magdaléna ONUŠČÁKOVÁ, Pavel BOBÁĽ and Peter KOLLÁR. Effects of novel hydroxamic acids on cell cycle progression and cytodifferentiation. In Student Scientific Conference MUNI PHARM 2022. 2022. ISBN 978-80-280-0106-3.
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Basic information
Original name Effects of novel hydroxamic acids on cell cycle progression and cytodifferentiation
Name in Czech Vliv nových hydroxamových kyselin na průběh buněčného cyklu a cytodiferenciaci
Authors MELICHAROVÁ, Jana (203 Czech Republic, belonging to the institution), Tereza KAUEROVÁ (203 Czech Republic, belonging to the institution), Magdaléna ONUŠČÁKOVÁ (703 Slovakia, belonging to the institution), Pavel BOBÁĽ (703 Slovakia, belonging to the institution) and Peter KOLLÁR (203 Czech Republic, belonging to the institution).
Edition Student Scientific Conference MUNI PHARM 2022, 2022.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14160/22:00129762
Organization unit Faculty of Pharmacy
ISBN 978-80-280-0106-3
Keywords in English histone deacetylase inhibitors; cell cycle; cytodifferentiation; vorinostat; hydroxamic acids
Tags rivok, ÚChL
Changed by Changed by: JUDr. Sabina Krejčiříková, učo 383857. Changed: 10/5/2023 16:14.
Abstract
At the Department of Chemical Drugs of the Pharmaceutical Faculty, Masaryk University, a new group of hydroxamic acids was designed and synthesized based on similarity to the structure of vorinostat. The aim of the project was to evaluate the effects of selected new hydroxamic acids on the processes of cell cycle progression and cytodifferentiation in the monocytic leukemia cell line and to compare these effects with the activity of a reference substance, vorinostat.
Abstract (in Czech)
Na Ústavu chemických léčiv Farmaceutické fakulty Masarykovy univerzity byla navržena a syntetizována nová skupina hydroxamových kyselin na základě jejich podobnosti se strukturou vorinostatu. Cílem projektu bylo zhodnotit účinky vybraných nových hydroxamových kyselin na procesy progrese buněčného cyklu a cytodiferenciace u buněčné linie monocytární leukémie a porovnat tyto účinky s aktivitou referenční látky, vorinostatu.
Links
MUNI/A/1598/2020, interní kód MUName: Analýza antiproliferačních, proapoptotických a cytodiferenciačních účinků nově syntetizovaných hydroxamových kyselin
Investor: Masaryk University
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