| TOMANDLOVÁ, Marie, Tomáš NOVOTNÝ, Robert STAFFA, Jindra SMUTNÁ, Tomáš KŘIVKA, Peter KRUŽLIAK, Ondřej SLABÝ, Luboš KUBÍČEK, Robert VLACHOVSKÝ, Lenka RADOVÁ and Josef TOMANDL. Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia. Clinical Biochemistry. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2023, vol. 112, February 2023, p. 43-47. ISSN 0009-9120. Available from: https://dx.doi.org/10.1016/j.clinbiochem.2022.12.002. |
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@article{2266100,
author = {Tomandlová, Marie and Novotný, Tomáš and Staffa, Robert and Smutná, Jindra and Křivka, Tomáš and Kružliak, Peter and Slabý, Ondřej and Kubíček, Luboš and Vlachovský, Robert and Radová, Lenka and Tomandl, Josef},
article_location = {OXFORD},
article_number = {February 2023},
doi = {http://dx.doi.org/10.1016/j.clinbiochem.2022.12.002},
keywords = {Acute intestinal ischemia; D -Lactate; Ischemia-modified albumin; Abdominal aortic aneurysm; Aortoiliac occlusive disease; Perioperative kinetics},
language = {eng},
issn = {0009-9120},
journal = {Clinical Biochemistry},
title = {Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia},
url = {https://www.sciencedirect.com/science/article/pii/S0009912022002715?via%3Dihub},
volume = {112},
year = {2023}
}
TY - JOUR
ID - 2266100
AU - Tomandlová, Marie - Novotný, Tomáš - Staffa, Robert - Smutná, Jindra - Křivka, Tomáš - Kružliak, Peter - Slabý, Ondřej - Kubíček, Luboš - Vlachovský, Robert - Radová, Lenka - Tomandl, Josef
PY - 2023
TI - Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia
JF - Clinical Biochemistry
VL - 112
IS - February 2023
SP - 43-47
EP - 43-47
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 00099120
KW - Acute intestinal ischemia
KW - D -Lactate
KW - Ischemia-modified albumin
KW - Abdominal aortic aneurysm
KW - Aortoiliac occlusive disease
KW - Perioperative kinetics
UR - https://www.sciencedirect.com/science/article/pii/S0009912022002715?via%3Dihub
N2 - Objectives: Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely. In this study the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) are described and the predictive value of these markers for the early diagnosis of acute intestinal ischemia is assessed.Design & methods: This non-randomised, single-centre cohort study enrolled 50 patients with abdominal aortic aneurysm (AAA) and 30 patients with aortoiliac occlusive disease (AOID). Serum D-lactate and IMA were assessed pre-, intra-, and postoperatively at eight defined time points.Results: The highest serum D-lactate was at 6 h after complete declamping of the vascular graft. The highest predictive power of D-lactate was at 3 h after complete declamping (AUC 0.857). IMA was found to be higher in the AAA group in ischemic patients 10 min after complete declamping than in the AOID group. The highest predictive values of IMA were at 1 h after aortic cross-clamping (AUC 0.758) and 3 and 6 h after complete declamping (0.745 and 0.721, respectively). Moreover, the multivariate model with both markers at 3 h after complete declamping improved the detection of intestinal ischemia (AUC 0.894).Conclusions: Serum levels of IMA and D-lactate seem to be influential predictive markers for postoperative intestinal ischemia, especially after 3 h from complete declamping of vascular reconstruction.
ER -
TOMANDLOVÁ, Marie, Tomáš NOVOTNÝ, Robert STAFFA, Jindra SMUTNÁ, Tomáš KŘIVKA, Peter KRUŽLIAK, Ondřej SLABÝ, Luboš KUBÍČEK, Robert VLACHOVSKÝ, Lenka RADOVÁ and Josef TOMANDL. Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia. \textit{Clinical Biochemistry}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2023, vol.~112, February 2023, p.~43-47. ISSN~0009-9120. Available from: https://dx.doi.org/10.1016/j.clinbiochem.2022.12.002.
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