Transient Reflexive Pain Responses and Chronic Affective
Nonreflexive Pain Responses Associated with Neuroinflammation
Processes in Both Spinal and Supraspinal Structures in Spinal
Cord-Injured Female Mice

J 2023

Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice

CASTANY, Sílvia, Anna BAGÓ MAS, José MIGUEL VELA, Enrique VERDÚ, Karolína BRETOVÁ et. al.

Basic information

Original name

Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice

Authors

CASTANY, Sílvia (724 Spain), Anna BAGÓ MAS (724 Spain, belonging to the institution), José MIGUEL VELA (724 Spain), Enrique VERDÚ (724 Spain), Karolína BRETOVÁ (203 Czech Republic, belonging to the institution), Viktorie SVOBODOVÁ (203 Czech Republic, belonging to the institution), Petr DUBOVÝ (203 Czech Republic, belonging to the institution) and Pere BOADAS-VAELLO (724 Spain, guarantor)

Edition

International Journal of Molecular Sciences, Basel, MDPI, 2023, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30106 Anatomy and morphology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.600 in 2022

RIV identification code

RIV/00216224:14110/23:00130444

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/ijms24021761

UT WoS

000918055000001

Keywords in English

spinal cord injury; central neuropathic pain; chronic pain; neuroinflammation; cytokines; chemokines; gliosis; CX3CL1/CX3CR1

Abstract

V originále

Central neuropathic pain is not only characterized by reflexive pain responses, but also emotional or affective nonreflexive pain responses, especially in women. Some pieces of evidence suggest that the activation of the neuroimmune system may be contributing to the manifestation of mood disorders in patients with chronic pain conditions, but the mechanisms that contribute to the development and chronicity of CNP and its associated disorders remain poorly understood. This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute SCI phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed that besides cytokines, the mPFC showed an increased glial activation as well as CX3CL1/CX3CR1 upregulation in the neurons, suggesting the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase.

Citovat

CASTANY, Sílvia, Anna BAGÓ MAS, José MIGUEL VELA, Enrique VERDÚ, Karolína BRETOVÁ, Viktorie SVOBODOVÁ, Petr DUBOVÝ and Pere BOADAS-VAELLO. Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice. International Journal of Molecular Sciences. Basel: MDPI, 2023, vol. 24, No 2, p. 1-23. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms24021761.

@article{2267258,
   author = {Castany, Sílvia and Bagó Mas, Anna and Miguel Vela, José and Verdú, Enrique and Bretová, Karolína and Svobodová, Viktorie and Dubový, Petr and BoadasandVaello, Pere},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/ijms24021761},
   keywords = {spinal cord injury; central neuropathic pain; chronic pain; neuroinflammation; cytokines; chemokines; gliosis; CX3CL1/CX3CR1},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice},
   url = {https://doi.org/10.3390/ijms24021761},
   volume = {24},
   year = {2023}
}

TY  - JOUR
ID  - 2267258
AU  - Castany, Sílvia - Bagó Mas, Anna - Miguel Vela, José - Verdú, Enrique - Bretová, Karolína - Svobodová, Viktorie - Dubový, Petr - Boadas-Vaello, Pere
PY  - 2023
TI  - Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice
JF  - International Journal of Molecular Sciences
VL  - 24
IS  - 2
SP  - 1-23
EP  - 1-23
PB  - MDPI
SN  - 14220067
KW  - spinal cord injury
KW  - central neuropathic pain
KW  - chronic pain
KW  - neuroinflammation
KW  - cytokines
KW  - chemokines
KW  - gliosis
KW  - CX3CL1/CX3CR1
UR  - https://doi.org/10.3390/ijms24021761
N2  - Central neuropathic pain is not only characterized by reflexive pain responses, but also emotional or affective nonreflexive pain responses, especially in women. Some pieces of evidence suggest that the activation of the neuroimmune system may be contributing to the manifestation of mood disorders in patients with chronic pain conditions, but the mechanisms that contribute to the development and chronicity of CNP and its associated disorders remain poorly understood. This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute SCI phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed that besides cytokines, the mPFC showed an increased glial activation as well as CX3CL1/CX3CR1 upregulation in the neurons, suggesting the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase.
ER  -

CASTANY, Sílvia, Anna BAGÓ MAS, José MIGUEL VELA, Enrique VERDÚ, Karolína BRETOVÁ, Viktorie SVOBODOVÁ, Petr DUBOVÝ and Pere BOADAS-VAELLO. Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2023, vol.~24, No~2, p.~1-23. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms24021761.

Detailed Information on Publication Record