| BRTKOVÁ, Barbora, Martina HERMANNOVÁ, Josef CHMELAŘ, Kristina NEŠPOROVÁ, Anna KOCURKOVÁ, Lukáš KUBALA, Gabriela AMBROŽOVÁ, Vladimír VELEBNÝ and Matěj ŠIMEK. Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies. Carbohydrate Polymers. Elsevier, 2023, vol. 299, January, p. 1-9. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2022.120201. |
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@article{2268520,
author = {Brtková, Barbora and Hermannová, Martina and Chmelař, Josef and Nešporová, Kristina and Kocurková, Anna and Kubala, Lukáš and Ambrožová, Gabriela and Velebný, Vladimír and Šimek, Matěj},
article_number = {January},
doi = {http://dx.doi.org/10.1016/j.carbpol.2022.120201},
keywords = {Hyaluronan derivatives; Implants; Degradation; Stable isotope; In -vivo evaluation},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies},
url = {https://doi.org/10.1016/j.carbpol.2022.120201},
volume = {299},
year = {2023}
}
TY - JOUR
ID - 2268520
AU - Brtková, Barbora - Hermannová, Martina - Chmelař, Josef - Nešporová, Kristina - Kocurková, Anna - Kubala, Lukáš - Ambrožová, Gabriela - Velebný, Vladimír - Šimek, Matěj
PY - 2023
TI - Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies
JF - Carbohydrate Polymers
VL - 299
IS - January
SP - 1-9
EP - 1-9
PB - Elsevier
SN - 01448617
KW - Hyaluronan derivatives
KW - Implants
KW - Degradation
KW - Stable isotope
KW - In -vivo evaluation
UR - https://doi.org/10.1016/j.carbpol.2022.120201
N2 - Hyaluronan is being investigated extensively as a biocompatible and biodegradable material for use in biomedical applications. While the derivatization of hyaluronan broadens its potential therapeutic use, the pharmacokinetics and metabolization of the derivatives must be thoroughly investigated. The fate of intraperitoneally-applied native and lauroyl-modified hyaluronan films with varying degrees of substitution was investigated in-vivo employing an exclusive stable isotope-labelling approach and LC-MS analysis. The materials were gradually degraded in peritoneal fluid, lymphatically absorbed, preferentially metabolized in the liver and eliminated without any observable accumulation in the body. Hyaluronan acylation prolongs its presence in the peritoneal cavity depending on the degree of substitution. The safety of acylated hyaluronan derivatives was confirmed via a metabolic study that revealed its degradation into non-toxic metabolites, i.e. native hyaluronan and free fatty acid. Stable isotope-labelling with LC-MS tracking comprises a high-quality procedure for the investigation of the metabolism and biodegradability of hyaluronan-based medical products in-vivo.
ER -
BRTKOVÁ, Barbora, Martina HERMANNOVÁ, Josef CHMELAŘ, Kristina NEŠPOROVÁ, Anna KOCURKOVÁ, Lukáš KUBALA, Gabriela AMBROŽOVÁ, Vladimír VELEBNÝ and Matěj ŠIMEK. Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies. \textit{Carbohydrate Polymers}. Elsevier, 2023, vol.~299, January, p.~1-9. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2022.120201.
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