J 2023

Influence of bacteriobilia on postoperative complications in patients with periampullary tumors

SVATOŇ, Roman, Vladimír PROCHÁZKA, Markéta HANSLIANOVÁ and Zdeněk KALA

Basic information

Original name

Influence of bacteriobilia on postoperative complications in patients with periampullary tumors

Authors

SVATOŇ, Roman (703 Slovakia, guarantor, belonging to the institution), Vladimír PROCHÁZKA (203 Czech Republic, belonging to the institution), Markéta HANSLIANOVÁ (203 Czech Republic, belonging to the institution) and Zdeněk KALA (203 Czech Republic, belonging to the institution)

Edition

Asian Journal of Surgery, SINGAPORE, ELSEVIER SINGAPORE PTE LTD, 2023, 1015-9584

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30212 Surgery

Country of publisher

Singapore

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.500 in 2022

RIV identification code

RIV/00216224:14110/23:00130476

Organization unit

Faculty of Medicine

DOI

UT WoS

000953399000001

Keywords in English

Bacteriobilia; Complications; Periampullary tumor

Tags

Tags

International impact, Reviewed
Změněno: 15/3/2024 10:11, Mgr. Tereza Miškechová

Abstract

V originále

Background Periampullary tumours (PAT) may cause obstruction of distal choledochus. The bile stasis is a risk factor for microbial colonisation of bile (bacteriobilia), cholangitis, hepatic insufficiency and coagulopathy. PAT obstruction can be managed surgically or non-operatively - by inserting a biliary drain or stent (BDS). Although BDS allows for adequate bile drainage, liver function restitution and coagulopathy, increased bacteriobilia has been reported and this is associated with an increased incidence of postoperative complications. Methods A monocentric, prospective, comparative study including 100 patients operated with PAT. The effects of bacteriobilia and the presence of a drain in the biliary tract on the development of postoperative complications were evaluated. Results Positive microbial findings in bile were found in 67% of patients. It was 98% in the biliary drain group vs. 36% in non-drained patients (p = 0.0001). In 68% 2 or more different bacterial strains were simultaneously present (p = 0.0001). Patients with a positive microbial finding in bile had more frequent incidence of infectious complications 40.2% (27) vs. 9.1% (3); p = 0.0011. The most frequent infectious complication was wound infection 29.8% (20) vs. 3.03% (1); p = 0.0014. Similarly, a higher incidence of postoperative infectious complications occurred in patients with BDS - 36% (18) vs. 24% (12); p = 0.2752. Conclusion The presence of a drain or stent in the biliary tract significantly increases the microbial colonisation of bile. It is associated with a significant increase in infectious complications, especially infections in the wound.