DVOŘÁK, Petr, Pavel KREJČÍ, Lukáš BÁLEK, Lívia EISELLEOVÁ, Žaneta KONEČNÁ, Pavel DVOŘÁK, David BEDNÁŘ, Jan BREZOVSKÝ, Eva ŠEBESTOVÁ, Radka CHALOUPKOVÁ, Veronika ŠTĚPÁNKOVÁ, Pavel VAŇÁČEK, Zbyněk PROKOP, Jiří DAMBORSKÝ and Michaela BOSÁKOVÁ. 熱安定性ＦＧＦ２ポリペプチド及びその使用 (Thermostable FGF2 polypeptide, use thereof). 2022.
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Basic information
Original name 熱安定性ＦＧＦ２ポリペプチド及びその使用
Name (in English) Thermostable FGF2 polypeptide, use thereof
Authors DVOŘÁK, Petr (203 Czech Republic, belonging to the institution), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), Lukáš BÁLEK (203 Czech Republic, belonging to the institution), Lívia EISELLEOVÁ (703 Slovakia, belonging to the institution), Žaneta KONEČNÁ (203 Czech Republic, belonging to the institution), Pavel DVOŘÁK (203 Czech Republic, belonging to the institution), David BEDNÁŘ (203 Czech Republic, belonging to the institution), Jan BREZOVSKÝ (203 Czech Republic, belonging to the institution), Eva ŠEBESTOVÁ (203 Czech Republic, belonging to the institution), Radka CHALOUPKOVÁ (203 Czech Republic, belonging to the institution), Veronika ŠTĚPÁNKOVÁ (203 Czech Republic), Pavel VAŇÁČEK (203 Czech Republic), Zbyněk PROKOP (203 Czech Republic), Jiří DAMBORSKÝ (203 Czech Republic, belonging to the institution) and Michaela BOSÁKOVÁ (203 Czech Republic, belonging to the institution).
Edition Number: JP7131772, Publisher: Japan Patent Office (JPO), Place of publication: Kasumigaseki Chiyoda-ku, Tokyo, Owner's name: Masarykova univerzita, Enantis, s.r.o. 2022.
Other information
Original language Japanese
Type of outcome Patent
Field of Study 10600 1.6 Biological sciences
Country of publisher Japan
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14310/22:00128920
Organization unit Faculty of Science
Keywords in English FGF2; Stem cells; Drugs
Tags rivok
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 22/3/2023 14:14.
Abstract
本発明は，ＦＧＦ２活性を有し，かつ配列番号：２（ＦＧＦ２ ｗｔ）の配列又はその断片に対して少なくとも８５％の配列同一性を有し，かつ，少なくともアミノ酸置換Ｒ３１Ｌを含む熱安定性ポリペプチド，及び，細胞生物学研究，再生医療及び関連する医療用途又は化粧品におけるその使用を提供する。本発明はさらにヒト胚性幹細胞と人工多能性幹細胞の両方を含むヒト多能性幹細胞の培養に適する，ＦＧＦ２を含む培地を開示する。
Abstract (in English)
The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
Links
LO1214, research and development projectName: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)
Investor: Ministry of Education, Youth and Sports of the CR
PrintDisplayed: 14/7/2024 09:55