DoE approach to optimize the spray drying process conditions
for the preparation of mannitol-based microparticles intended
for pulmonary administration

a 2023

DoE approach to optimize the spray drying process conditions for the preparation of mannitol-based microparticles intended for pulmonary administration

PAVLOKOVÁ, Sylvie, Jakub KARAS, Hana HOŘAVOVÁ and Jan GAJDZIOK

Basic information

Original name

DoE approach to optimize the spray drying process conditions for the preparation of mannitol-based microparticles intended for pulmonary administration

Authors

PAVLOKOVÁ, Sylvie, Jakub KARAS, Hana HOŘAVOVÁ and Jan GAJDZIOK

Edition

4th European Conference on Pharmaceutics, 2023

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Webová stránka konference

Organization unit

Faculty of Pharmacy

Keywords in English

spray drying; microparticles; mannitol; pulmonary administration; design of experiments; multiple linear regression; perspective plots

Abstract

V originále

Nowadays, the optimization of process/formulation parameters represents an important step in research, and the design of experiment (DoE) approach is getting great attention in the field of pharmaceutical technology. In order to understand the relationship among input variables and response(s) or directly to find optimal process settings while achieving high efficiency and low costs at the same time, response surface methodology (RSM) is widely used. A suitable tool for RSM application when having 2–4 independent factors is Box-Behnken design (BBD), which is also sufficient to fit a quadratic model. The present study was focused on investigating of mannitol-based microparticles prepared by the spray drying method and intended for pulmonary administration mediated by inhalation. The effects of spray drying process parameters on the particle size were investigated employing BBD and DoE data analysis. Mass median aerodynamic diameter (MMAD) was selected as the characteristic of particle size. Particles of the MMAD in the interval of 1– 5 μm reach the deep lungs represented by small airways and alveoli, which is desired.

Citovat

PAVLOKOVÁ, Sylvie, Jakub KARAS, Hana HOŘAVOVÁ and Jan GAJDZIOK. DoE approach to optimize the spray drying process conditions for the preparation of mannitol-based microparticles intended for pulmonary administration. In 4th European Conference on Pharmaceutics. 2023.

@proceedings{2270438,
   author = {Pavloková, Sylvie and Karas, Jakub and Hořavová, Hana and Gajdziok, Jan},
   booktitle = {4th European Conference on Pharmaceutics},
   keywords = {spray drying; microparticles; mannitol; pulmonary administration; design of experiments; multiple linear regression; perspective plots},
   language = {eng},
   title = {DoE approach to optimize the spray drying process conditions for the preparation of mannitol-based microparticles intended for pulmonary administration},
   url = {https://www.europeanmeeting.org/home/},
   year = {2023}
}

TY  - CONF
ID  - 2270438
AU  - Pavloková, Sylvie - Karas, Jakub - Hořavová, Hana - Gajdziok, Jan
PY  - 2023
TI  - DoE approach to optimize the spray drying process conditions for the preparation of mannitol-based microparticles intended for pulmonary administration
KW  - spray drying
KW  - microparticles
KW  - mannitol
KW  - pulmonary administration
KW  - design of experiments
KW  - multiple linear regression
KW  - perspective plots
UR  - https://www.europeanmeeting.org/home/
N2  - Nowadays, the optimization of process/formulation parameters represents an important step in research, and the design of experiment (DoE) approach is getting great attention in the field of pharmaceutical technology. In order to understand the relationship among input variables and response(s) or directly to find optimal process settings while achieving high efficiency and low costs at the same time, response surface methodology (RSM) is widely used. A suitable tool for RSM application when having 2–4 independent factors is Box-Behnken design (BBD), which is also sufficient to fit a quadratic model. The present study was focused on investigating of mannitol-based microparticles prepared by the spray drying method and intended for pulmonary administration mediated by inhalation. The effects of spray drying process parameters on the particle size were investigated employing BBD and DoE data analysis. Mass median aerodynamic diameter (MMAD) was selected as the characteristic of particle size. Particles of the MMAD in the interval of 1– 5 μm reach the deep lungs represented by small airways and alveoli, which is desired.
ER  -

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