In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

BALAZOVA, Ludmila, Tomáš WOLASCHKA, Simona ROHAĽOVÁ, Nina DANEU, Martin STAHORSKY, Aneta SALAYOVA, Ludmila TKACIKOVA and Jarmila EFTIMOVA. In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity. LIFE-BASEL. BASEL: MDPI, 2023, vol. 13, No 2, p. 1-20. ISSN 2075-1729. Available from: https://dx.doi.org/10.3390/life13020573.

Basic information

• Original name: In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity
• Authors: BALAZOVA, Ludmila (guarantor), Tomáš WOLASCHKA (703 Slovakia), Simona ROHAĽOVÁ (703 Slovakia, belonging to the institution), Nina DANEU, Martin STAHORSKY, Aneta SALAYOVA, Ludmila TKACIKOVA and Jarmila EFTIMOVA.
• Edition: LIFE-BASEL, BASEL, MDPI, 2023, 2075-1729.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.200 in 2022
• RIV identification code: RIV/00216224:14160/23:00130503
• Organization unit: Faculty of Pharmacy
• Doi: http://dx.doi.org/10.3390/life13020573
• UT WoS: 000941440700001
• Keywords in English: nanoparticles; silver; Agrimonia eupatoria; in situ gel
• Tags: rivok, ÚFT
• Tags: International impact, Reviewed

Abstract

Silver nanoparticles (Ag NPs) with antibacterial activity can be prepared in different ways. In our case, we used ecological green synthesis with Agrimonia eupatoria L. The plant extract was used with Ag NPs for the first time to prepare termosensitive in situ gels (ISGs). Such gels are used to heal human or animal skin and mucous membranes, as they can change from a liquid to solid state after application. Ag NPs were characterized with various techniques (FTIR, TEM, size distribution, zeta potential) and their antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. In accordance with the TEM data, we prepared monodispersed spherical Ag NPs with an average size of about 20 nm. Organic active compounds from Agrimonia eupatoria L. were found on their surfaces using FTIR spectroscopy. Surprisingly, only the in situ gel with Ag NPs showed antibacterial activity against Escherichia coli, while Ag NPs alone did not. Ag NPs prepared via green synthesis using plants with medicinal properties and incorporated into ISGs have great potential for wound healing due to the antibacterial activity of Ag NPs and the dermatological activity of organic substances from plants.