Optimization of Spray Drying Process Parameters for the
Preparation of Inhalable Mannitol-Based Microparticles Using a
Box-Behnken Experimental Design

J 2023

Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design

KARAS, Jakub, Sylvie PAVLOKOVÁ, Hana HOŘAVOVÁ and Jan GAJDZIOK

Basic information

Original name

Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design

Authors

KARAS, Jakub (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), Hana HOŘAVOVÁ (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Pharmaceutics, Basel, MDPI, 2023, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.400 in 2022

RIV identification code

RIV/00216224:14160/23:00130533

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/pharmaceutics15020496

UT WoS

000940971800001

Keywords in English

large porous particles; spray drying; mannitol; inhalation; microparticles' properties; process parameters; Box-Behnken design; multiple linear regression

Abstract

V originále

Inhalation is used for local therapy of the lungs and as an alternative route for systemic drug delivery. Modern powder inhalation systems try to target the required site of action/absorption in the respiratory tract. Large porous particles (LPPs) with a size >5 μm and a low mass density (usually measured as bulk or tapped) of <0.4 g/cm3 can avoid protective lung mechanisms. Their suitable aerodynamic properties make them perspective formulations for deep lung deposition. This experiment studied the effect of spray-drying process parameters on LPP properties. An experimental design of twelve experiments with a central point was realized using the Box–Behnken method. Three process parameters (drying temperature, pump speed, and air speed) were combined on three levels. Particles were formed from a D-mannitol solution, representing a perspective material for lung microparticles. The microparticles were characterized in terms of physical size (laser diffraction), aerodynamic diameter (aerodynamic particle sizer), morphology (SEM), and densities. The novelty and main goal of this research were to describe how the complex parameters of the spray-drying process affect the properties of mannitol LPPs. New findings can provide valuable data to other researchers, leading to the easy tuning of the properties of spray-dried particles by changing the process setup.

Links

MUNI/A/1140/2021, interní kód MU

Name: Optimalizace porozity mikročástic pro plicní aplikaci (Acronym: porogeny)

Investor: Masaryk University

Citovat

KARAS, Jakub, Sylvie PAVLOKOVÁ, Hana HOŘAVOVÁ and Jan GAJDZIOK. Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design. Pharmaceutics. Basel: MDPI, 2023, vol. 15, No 2, p. 1-16. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15020496.

@article{2271997,
   author = {Karas, Jakub and Pavloková, Sylvie and Hořavová, Hana and Gajdziok, Jan},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/pharmaceutics15020496},
   keywords = {large porous particles; spray drying; mannitol; inhalation; microparticles' properties; process parameters; Box-Behnken design; multiple linear regression},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design},
   url = {https://www.mdpi.com/1999-4923/15/2/496},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2271997
AU  - Karas, Jakub - Pavloková, Sylvie - Hořavová, Hana - Gajdziok, Jan
PY  - 2023
TI  - Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design
JF  - Pharmaceutics
VL  - 15
IS  - 2
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 19994923
KW  - large porous particles
KW  - spray drying
KW  - mannitol
KW  - inhalation
KW  - microparticles' properties
KW  - process parameters
KW  - Box-Behnken design
KW  - multiple linear regression
UR  - https://www.mdpi.com/1999-4923/15/2/496
N2  - Inhalation is used for local therapy of the lungs and as an alternative route for systemic drug delivery. Modern powder inhalation systems try to target the required site of action/absorption in the respiratory tract. Large porous particles (LPPs) with a size >5 μm and a low mass density (usually measured as bulk or tapped) of <0.4 g/cm3 can avoid protective lung mechanisms. Their suitable aerodynamic properties make them perspective formulations for deep lung deposition. This experiment studied the effect of spray-drying process parameters on LPP properties. An experimental design of twelve experiments with a central point was realized using the Box–Behnken method. Three process parameters (drying temperature, pump speed, and air speed) were combined on three levels. Particles were formed from a D-mannitol solution, representing a perspective material for lung microparticles. The microparticles were characterized in terms of physical size (laser diffraction), aerodynamic diameter (aerodynamic particle sizer), morphology (SEM), and densities. The novelty and main goal of this research were to describe how the complex parameters of the spray-drying process affect the properties of mannitol LPPs. New findings can provide valuable data to other researchers, leading to the easy tuning of the properties of spray-dried particles by changing the process setup.
ER  -

KARAS, Jakub, Sylvie PAVLOKOVÁ, Hana HOŘAVOVÁ and Jan GAJDZIOK. Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design. \textit{Pharmaceutics}. Basel: MDPI, 2023, vol.~15, No~2, p.~1-16. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15020496.

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