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@article{2271997,
author = {Karas, Jakub and Pavloková, Sylvie and Hořavová, Hana and Gajdziok, Jan},
article_location = {Basel},
article_number = {2},
doi = {http://dx.doi.org/10.3390/pharmaceutics15020496},
keywords = {large porous particles; spray drying; mannitol; inhalation; microparticles' properties; process parameters; Box-Behnken design; multiple linear regression},
language = {eng},
issn = {1999-4923},
journal = {Pharmaceutics},
title = {Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design},
url = {https://www.mdpi.com/1999-4923/15/2/496},
volume = {15},
year = {2023}
}
TY - JOUR
ID - 2271997
AU - Karas, Jakub - Pavloková, Sylvie - Hořavová, Hana - Gajdziok, Jan
PY - 2023
TI - Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design
JF - Pharmaceutics
VL - 15
IS - 2
SP - 1-16
EP - 1-16
PB - MDPI
SN - 19994923
KW - large porous particles
KW - spray drying
KW - mannitol
KW - inhalation
KW - microparticles' properties
KW - process parameters
KW - Box-Behnken design
KW - multiple linear regression
UR - https://www.mdpi.com/1999-4923/15/2/496
N2 - Inhalation is used for local therapy of the lungs and as an alternative route for systemic drug delivery. Modern powder inhalation systems try to target the required site of action/absorption in the respiratory tract. Large porous particles (LPPs) with a size >5 μm and a low mass density (usually measured as bulk or tapped) of <0.4 g/cm3 can avoid protective lung mechanisms. Their suitable aerodynamic properties make them perspective formulations for deep lung deposition. This experiment studied the effect of spray-drying process parameters on LPP properties. An experimental design of twelve experiments with a central point was realized using the Box–Behnken method. Three process parameters (drying temperature, pump speed, and air speed) were combined on three levels. Particles were formed from a D-mannitol solution, representing a perspective material for lung microparticles. The microparticles were characterized in terms of physical size (laser diffraction), aerodynamic diameter (aerodynamic particle sizer), morphology (SEM), and densities. The novelty and main goal of this research were to describe how the complex parameters of the spray-drying process affect the properties of mannitol LPPs. New findings can provide valuable data to other researchers, leading to the easy tuning of the properties of spray-dried particles by changing the process setup.
ER -
KARAS, Jakub, Sylvie PAVLOKOVÁ, Hana HOŘAVOVÁ and Jan GAJDZIOK. Optimization of Spray Drying Process Parameters for the Preparation of Inhalable Mannitol-Based Microparticles Using a Box-Behnken Experimental Design. \textit{Pharmaceutics}. Basel: MDPI, 2023, vol.~15, No~2, p.~1-16. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15020496.
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