Radiopaque Nanorobots as Magnetically Navigable Contrast Agents
for Localized In Vivo Imaging of the Gastrointestinal Tract

J 2023

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

ORAL, Cagatay M., Martina USSIA, Mario URSO, Jiří SALÁT, Adam NOVOBILSKY et. al.

Basic information

Original name

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Authors

ORAL, Cagatay M., Martina USSIA, Mario URSO, Jiří SALÁT (203 Czech Republic), Adam NOVOBILSKY, Michal STEFANIK, Daniel RŮŽEK (203 Czech Republic, belonging to the institution) and Martin PUMERA (guarantor)

Edition

Advanced Healthcare Materials, Wiley, 2023, 2192-2640

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10405 Electrochemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.000 in 2022

RIV identification code

RIV/00216224:14310/23:00130535

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/adhm.202202682

UT WoS

000903078100001

Keywords in English

computed tomography; gastrointestinal tract; magnetic actuation; medical imaging; nanomotors; nanoswimmers; tracking

Abstract

V originále

Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo.

Citovat

ORAL, Cagatay M., Martina USSIA, Mario URSO, Jiří SALÁT, Adam NOVOBILSKY, Michal STEFANIK, Daniel RŮŽEK and Martin PUMERA. Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract. Advanced Healthcare Materials. Wiley, 2023, vol. 12, No 8, p. 1-9. ISSN 2192-2640. Available from: https://dx.doi.org/10.1002/adhm.202202682.

@article{2272057,
   author = {Oral, Cagatay M. and Ussia, Martina and Urso, Mario and Salát, Jiří and Novobilsky, Adam and Stefanik, Michal and Růžek, Daniel and Pumera, Martin},
   article_number = {8},
   doi = {http://dx.doi.org/10.1002/adhm.202202682},
   keywords = {computed tomography; gastrointestinal tract; magnetic actuation; medical imaging; nanomotors; nanoswimmers; tracking},
   language = {eng},
   issn = {2192-2640},
   journal = {Advanced Healthcare Materials},
   title = {Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract},
   url = {https://doi.org/10.1002/adhm.202202682},
   volume = {12},
   year = {2023}
}

TY  - JOUR
ID  - 2272057
AU  - Oral, Cagatay M. - Ussia, Martina - Urso, Mario - Salát, Jiří - Novobilsky, Adam - Stefanik, Michal - Růžek, Daniel - Pumera, Martin
PY  - 2023
TI  - Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
JF  - Advanced Healthcare Materials
VL  - 12
IS  - 8
SP  - 1-9
EP  - 1-9
PB  - Wiley
SN  - 21922640
KW  - computed tomography
KW  - gastrointestinal tract
KW  - magnetic actuation
KW  - medical imaging
KW  - nanomotors
KW  - nanoswimmers
KW  - tracking
UR  - https://doi.org/10.1002/adhm.202202682
N2  - Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo.
ER  -

ORAL, Cagatay M., Martina USSIA, Mario URSO, Jiří SALÁT, Adam NOVOBILSKY, Michal STEFANIK, Daniel RŮŽEK and Martin PUMERA. Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract. \textit{Advanced Healthcare Materials}. Wiley, 2023, vol.~12, No~8, p.~1-9. ISSN~2192-2640. Available from: https://dx.doi.org/10.1002/adhm.202202682.

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